Seasonal variation in human central dopamine activity

Craig N. Karson, Karen Faith Berman, Joel Kleinman, Farouk Karoum

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


This report focuses on two studies of seasonal variation of central dopamine activity in patients with schizophrenia and normal controls. In the two investigations, data were grouped and analyzed by season (i.e., spring-summer vs. fall-winter). The first study concerned blink rate, a putative measure of central dopamine activity; the blink rate for patients with schizophrenia was significantly increased during the spring-summer period. In the second study concentrations of catecholamines and their metabolites were measured in the hypothalamus and nucleus accumbens of normal and schizophrenic subjects. Findings include a reduced concentration of hypothalamus dopamine in normal controls and a reduced concentration of homovanillic acid in the nucleus accumbens of patients with schizophrenia, both during the spring-summer period.

Original languageEnglish (US)
Pages (from-to)111-117
Number of pages7
JournalPsychiatry research
Issue number2
StatePublished - Feb 1984
Externally publishedYes


  • Dopamine
  • blink rate
  • homovanillic acid
  • seasonal variation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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