Screening for Human Immunodeficiency Virus Infections

Michael A. Stoto; Richard Londo; Richard L. Vogt; Deborah Kutzko; Kevin V. Kelly; Donald S. Burke; John F. Brundage; Robert R. Redfield; James J. Damato; Robin Weiss; Samuel O. Thier

doi:10.1056/NEJM198902163200711

Screening for Human Immunodeficiency Virus Infections

Michael A. Stoto, Richard Londo, Richard L. Vogt, Deborah Kutzko, Kevin V. Kelly, Donald S. Burke, John F. Brundage, Robert R. Redfield, James J. Damato, Robin Weiss, Samuel O. Thier

Research output: Contribution to journal › Letter › peer-review

Abstract

To the Editor: Burke et al. (Oct. 13 issue)¹ obtain impressive results in their study of false positive results in the U.S. Army's human immunodeficiency virus (HIV) screening program for service applicants. The extrapolation of these results to populations other than the specific low-risk population on which the test was based is problematic, however. Such extrapolation requires two steps. First, the test's sensitivity and specificity must be determined. Burke et al. implicitly assume that there were no false negatives, and hence that the sequence of tests had a sensitivity (the probability that a true positive specimen will test positive) of…

Original language	English (US)
Pages (from-to)	461-463
Number of pages	3
Journal	New England Journal of Medicine
Volume	320
Issue number	7
DOIs	https://doi.org/10.1056/NEJM198902163200711
State	Published - Feb 16 1989
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1056/NEJM198902163200711

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title = "Screening for Human Immunodeficiency Virus Infections",

abstract = "To the Editor: Burke et al. (Oct. 13 issue)1 obtain impressive results in their study of false positive results in the U.S. Army's human immunodeficiency virus (HIV) screening program for service applicants. The extrapolation of these results to populations other than the specific low-risk population on which the test was based is problematic, however. Such extrapolation requires two steps. First, the test's sensitivity and specificity must be determined. Burke et al. implicitly assume that there were no false negatives, and hence that the sequence of tests had a sensitivity (the probability that a true positive specimen will test positive) of…",

author = "Stoto, {Michael A.} and Richard Londo and Vogt, {Richard L.} and Deborah Kutzko and Kelly, {Kevin V.} and Burke, {Donald S.} and Brundage, {John F.} and Redfield, {Robert R.} and Damato, {James J.} and Robin Weiss and Thier, {Samuel O.}",

year = "1989",

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doi = "10.1056/NEJM198902163200711",

language = "English (US)",

volume = "320",

pages = "461--463",

journal = "New England Journal of Medicine",

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TY - JOUR

T1 - Screening for Human Immunodeficiency Virus Infections

AU - Stoto, Michael A.

AU - Londo, Richard

AU - Vogt, Richard L.

AU - Kutzko, Deborah

AU - Kelly, Kevin V.

AU - Burke, Donald S.

AU - Brundage, John F.

AU - Redfield, Robert R.

AU - Damato, James J.

AU - Weiss, Robin

AU - Thier, Samuel O.

PY - 1989/2/16

Y1 - 1989/2/16

N2 - To the Editor: Burke et al. (Oct. 13 issue)1 obtain impressive results in their study of false positive results in the U.S. Army's human immunodeficiency virus (HIV) screening program for service applicants. The extrapolation of these results to populations other than the specific low-risk population on which the test was based is problematic, however. Such extrapolation requires two steps. First, the test's sensitivity and specificity must be determined. Burke et al. implicitly assume that there were no false negatives, and hence that the sequence of tests had a sensitivity (the probability that a true positive specimen will test positive) of…

AB - To the Editor: Burke et al. (Oct. 13 issue)1 obtain impressive results in their study of false positive results in the U.S. Army's human immunodeficiency virus (HIV) screening program for service applicants. The extrapolation of these results to populations other than the specific low-risk population on which the test was based is problematic, however. Such extrapolation requires two steps. First, the test's sensitivity and specificity must be determined. Burke et al. implicitly assume that there were no false negatives, and hence that the sequence of tests had a sensitivity (the probability that a true positive specimen will test positive) of…

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DO - 10.1056/NEJM198902163200711

M3 - Letter

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JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 7

ER -

Screening for Human Immunodeficiency Virus Infections

Abstract

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