Screening for Human Immunodeficiency Virus Infections

Michael A. Stoto, Richard Londo, Richard L. Vogt, Deborah Kutzko, Kevin V. Kelly, Donald S. Burke, John F. Brundage, Robert R. Redfield, James J. Damato, Robin Weiss, Samuel O. Thier

Research output: Contribution to journalLetterpeer-review


To the Editor: Burke et al. (Oct. 13 issue)1 obtain impressive results in their study of false positive results in the U.S. Army's human immunodeficiency virus (HIV) screening program for service applicants. The extrapolation of these results to populations other than the specific low-risk population on which the test was based is problematic, however. Such extrapolation requires two steps. First, the test's sensitivity and specificity must be determined. Burke et al. implicitly assume that there were no false negatives, and hence that the sequence of tests had a sensitivity (the probability that a true positive specimen will test positive) of…

Original languageEnglish (US)
Pages (from-to)461-463
Number of pages3
JournalNew England Journal of Medicine
Issue number7
StatePublished - Feb 16 1989
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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