Scratching the surface of itch receptors

Ruchita Kothari; Xinzhong Dong

doi:10.1016/j.tips.2021.12.005

Scratching the surface of itch receptors

Ruchita Kothari, Xinzhong Dong

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

Abstract

The discovery of Mas-related G protein-coupled receptors (MRGPRs) in itch sensation promised a search for novel therapeutics of itch that ultimately met with little success. Recent structural determination of these receptors by Roth and Sun marks a big step forward in the search for therapeutics of debilitating itch.

Original language	English (US)
Pages (from-to)	168-170
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/j.tips.2021.12.005
State	Published - Mar 2022

Keywords

DRG neuron
MRGPRs
cryoEM
itch
mast cell
structure

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1016/j.tips.2021.12.005

Cite this

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title = "Scratching the surface of itch receptors",

abstract = "The discovery of Mas-related G protein-coupled receptors (MRGPRs) in itch sensation promised a search for novel therapeutics of itch that ultimately met with little success. Recent structural determination of these receptors by Roth and Sun marks a big step forward in the search for therapeutics of debilitating itch.",

keywords = "DRG neuron, MRGPRs, cryoEM, itch, mast cell, structure",

author = "Ruchita Kothari and Xinzhong Dong",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2022",

month = mar,

doi = "10.1016/j.tips.2021.12.005",

language = "English (US)",

volume = "43",

pages = "168--170",

journal = "Trends in Pharmacological Sciences",

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T1 - Scratching the surface of itch receptors

AU - Kothari, Ruchita

AU - Dong, Xinzhong

PY - 2022/3

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N2 - The discovery of Mas-related G protein-coupled receptors (MRGPRs) in itch sensation promised a search for novel therapeutics of itch that ultimately met with little success. Recent structural determination of these receptors by Roth and Sun marks a big step forward in the search for therapeutics of debilitating itch.

AB - The discovery of Mas-related G protein-coupled receptors (MRGPRs) in itch sensation promised a search for novel therapeutics of itch that ultimately met with little success. Recent structural determination of these receptors by Roth and Sun marks a big step forward in the search for therapeutics of debilitating itch.

KW - DRG neuron

KW - MRGPRs

KW - cryoEM

KW - itch

KW - mast cell

KW - structure

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U2 - 10.1016/j.tips.2021.12.005

DO - 10.1016/j.tips.2021.12.005

M3 - Short survey

C2 - 35039148

AN - SCOPUS:85122934271

SN - 0165-6147

VL - 43

SP - 168

EP - 170

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 3

ER -

Scratching the surface of itch receptors

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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