TY - JOUR
T1 - Schizophrenia, the heteromodal association neocortex and development
T2 - Potential for a neurogenetic approach
AU - Ross, C. A.
AU - Pearlson, G. D.
N1 - Funding Information:
We thank Patrick Barta, Nancy Johnston, Marla Luskin, Russell Margolis, Paul McHugh, John Rubinstein, Solomon Snyder, Fuller Torrey, Frances Yee and Robert Yolken for discussions and suggestions, or for reading the manuscript or both. Frances Yee provided suggestions on PCR methods. We thank members of the Stanley Laboratory for discussions. We thank Debbie Pollard for expert assistance with manuscript preparation. Melissa Frederickse produced the figures. C.A. Ross was supported by NIH MH43040 and 50763 and NS16375 grants, a NARSAD Established Investigator Award, and grants from the Stanley Foundation and Scottish Rite Schizophrenia Foundation. G.D. Pearlson was supported by NIH AG11859-01, MH43775-05, MH43326-05 and OP-GCRC RR00722 grants.
PY - 1996/5
Y1 - 1996/5
N2 - The heteromodal association neocortex is believed to be a major site of involvement in schizophrenia. This system includes the prefrontal cortex and portions of the superior temporal and inferior parietal cortices, which are linked in cognitive networks observing complex executive functions. The heteromodal cortex is highly elaborated in humans and is believed to continue to develop past birth. The neuropathology of schizophrenia is likely to be heterogeneous and appears to involve developmental abnormalities, with a prominent genetic component. However, the genes involved in the development of the neocortex, and particularly the heteromodal cortex, are not well understood. A candidate-gene approach to schizophrenia using techniques of differential expression might now be feasible and could illuminate the basic neurobiology of the heteromodal cortical network.
AB - The heteromodal association neocortex is believed to be a major site of involvement in schizophrenia. This system includes the prefrontal cortex and portions of the superior temporal and inferior parietal cortices, which are linked in cognitive networks observing complex executive functions. The heteromodal cortex is highly elaborated in humans and is believed to continue to develop past birth. The neuropathology of schizophrenia is likely to be heterogeneous and appears to involve developmental abnormalities, with a prominent genetic component. However, the genes involved in the development of the neocortex, and particularly the heteromodal cortex, are not well understood. A candidate-gene approach to schizophrenia using techniques of differential expression might now be feasible and could illuminate the basic neurobiology of the heteromodal cortical network.
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U2 - 10.1016/S0166-2236(96)10022-9
DO - 10.1016/S0166-2236(96)10022-9
M3 - Article
C2 - 8723199
AN - SCOPUS:0029876529
SN - 0166-2236
VL - 19
SP - 171
EP - 176
JO - Trends in neurosciences
JF - Trends in neurosciences
IS - 5
ER -