Abstract
Tissue engineering, with the use of cells and scaffolds, has important clinical application in regenerative medicine. Additionally, these technologies can also be applied to the study of cellular biology, specifically, the cellular interactions within organized scaffolds, and the effects of paracrine communication between different cell types. The main focus of this chapter will be on the cell-matrix interactions and the communications between normal and diseased cells within organized scaffolds. In addition, this chapter will review the different cell types utilized in musculoskeletal tissue engineering with a focus on the application of mesenchymal stem cells in therapeutic scenarios, summarize the use of natural and synthetic biomaterials in tissue engineering and their combination into organized scaffolds, and discuss how cytokines affect tissue growth and disease development through the stimulation of matrix metalloproteinases.
| Original language | English (US) |
|---|---|
| Title of host publication | Regenerative Medicine and Biomaterials for the Repair of Connective Tissues |
| Publisher | Elsevier Ltd |
| Pages | 301-329 |
| Number of pages | 29 |
| ISBN (Print) | 9781845694173 |
| DOIs | |
| State | Published - Jan 2010 |
Keywords
- Matrix metalloproteinases
- Mesenchymal stem cells
- Osteoarthritis
- Paracrine communication
- Scaffolds
ASJC Scopus subject areas
- General Materials Science