@article{0ab1040830d942ad9ab3ec2353e03719,
title = "Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination",
abstract = "Milbreta et al. demonstrate that the non-viral delivery of miR-219 and miR-338 using a hybrid electrospun fiber-hydrogel scaffold can promote the survival of oligodendrocyte progenitor cells (OPCs) in a lacerated spinal cord. Besides that, this cocktail can enhance the rate and extent of OPC differentiation and subsequent remyelination in the implant interface and within the scaffold.",
keywords = "CNS, electrospinning, gene silencing, microRNA, myelination, non-viral, oligodendrocytes, regeneration, scaffold, sustained",
author = "Ulla Milbreta and Junquan Lin and Coline Pinese and William Ong and Chin, {Jiah Shin} and Hitomi Shirahama and Ruifa Mi and Anna Williams and Bechler, {Marie E.} and Jun Wang and Charles ffrench-Constant and Ahmet Hoke and Chew, {Sing Yian}",
note = "Funding Information: Partial funding support was provided by the Singapore National Research Foundation under its NMRC-CBRG grants ( NMRC/CBRG/0002/2012 and NMRC/CBRG/0096/2015 ) and administered by the Singapore Ministry of Health{\textquoteright}s National Medical Research Council . The MOE Tier 1 grant ( RG148/14 ) and the RRIS Rehabilitation Research Grant ( RRG1/16004 ) are acknowledged. Partial funding support from the Dr. Miriam and Sheldon G. Adelson Research Foundation is also acknowledged. The authors would like to thank Prof. William Stallcup for his generous gift of the anti-PDGFRα antibody, and Prof. Jonah Chan for the meaningful discussions on oligodendrocyte differentiation and markers expressions. Funding Information: Partial funding support was provided by the Singapore National Research Foundation under its NMRC-CBRG grants (NMRC/CBRG/0002/2012 and NMRC/CBRG/0096/2015) and administered by the Singapore Ministry of Health's National Medical Research Council. The MOE Tier 1 grant (RG148/14) and the RRIS Rehabilitation Research Grant (RRG1/16004) are acknowledged. Partial funding support from the Dr. Miriam and Sheldon G. Adelson Research Foundation is also acknowledged. The authors would like to thank Prof. William Stallcup for his generous gift of the anti-PDGFR? antibody, and Prof. Jonah Chan for the meaningful discussions on oligodendrocyte differentiation and markers expressions. Publisher Copyright: {\textcopyright} 2018 The American Society of Gene and Cell Therapy",
year = "2019",
month = feb,
day = "6",
doi = "10.1016/j.ymthe.2018.11.016",
language = "English (US)",
volume = "27",
pages = "411--423",
journal = "Molecular Therapy",
issn = "1525-0016",
publisher = "Nature Publishing Group",
number = "2",
}