Sarcopenia-related parameters and incident disability in older persons: Results from the "Invecchiare in Chianti" study

Matteo Cesari, Yves Rolland, Gabor Abellan Van Kan, Stefania Bandinelli, Bruno Vellas, Luigi Ferrucci

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Background. Current operational definitions of sarcopenia are based on algorithms' simultaneous considering measures of skeletal muscle mass and muscle-specific as well as global function. We hypothesize that quantitative and qualitative sarcopenia-related parameters may not be equally predictive of incident disability, thus presenting different clinical relevance. Methods. Data are from 922 elder adults (mean age = 73.9 years) with no activities of daily living (ADL) impairment recruited in the "Invecchiare in Chianti" study. Incident disability in ≥ 1 ADL defined the outcome of interest. The specific capacities of following sarcopenia-related parameters at predicting incident ADL disability were compared: residuals of skeletal muscle mass, fat-adjusted residuals of skeletal muscle mass, muscle density, ankle extension strength, ratio ankle extension strength/muscle mass, gait speed, and handgrip strength. Results. During the follow-up (median = 9.1 years), 188 (20.4%) incident ADL disability events were reported. Adjusted models showed that only gait speed was significantly associated with the outcome in both men (per standard deviation [SD] = 0.23 m/s increase, hazard ratio [HR] = 0.46, 95% confidence interval [CI] = 0.33-0.63; p

Original languageEnglish (US)
Pages (from-to)457-463
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number4
StatePublished - Apr 1 2015
Externally publishedYes


  • Body composition
  • Disability
  • Gait speed
  • Sarcopenia
  • Skeletal muscle

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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