Safety and immunogenicity of multiple conventional immunizations administered during early HIV infection

Joanne I. Rhoads, Deborah L. Birn, D. Craig Wright, John F. Brundage, Brenda L. Brandt, Robert R. Redfield, Donald S. Burke

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Twenty-one asymptomatic adults who had recently received multiple polysaccharide, live viral, and protein-derived vaccines were identified as being infected with human immunodeficiency virus (HIV). The mean subject age was 24 years trange 18;33; 20 of 21 (95) were male. The mean T4 count was 523 mm with a mean T1.T8 ratio of 0.6. Serologic responses to immunization with meningococcus group C. adenovirus types 4 and 7, tetanus, and dephteria were evaluated for the HIV seropositive subjects and were compared with the responses of similarly vaccinated age, sex, and race-matched HIV-seronegative controls. Significantly fewer (p = 0.03) HIV subjects responded to meningococcus C (bactericidal antibody) and adenovirus 4 (neutralizing antibody) vaccines that did normals; the HIV-infected subjects who Booster responses of HIV subjects to tetanus and diphthera were comparable to those of normals. HIV-infected vaccine nonresponders did not differ from HIV-infected tesponders in total white blood cell. T1, T4, T8, total serum IgG, or delayed-type hypersensitivity skin test reactivity. All HIV subjects had negative cultures for live vaccine viruses (rubella, measles, adenovirus, and poliovirus). Postimmunization, no clinically apparent adverse reactions to vaceination were detected.

Original languageEnglish (US)
Pages (from-to)724-731
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number7
StatePublished - Jul 1991
Externally publishedYes


  • HIV
  • Immunizations
  • Immunogenietty

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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