Safety and immunogenicity of intramuscular and intravaginal delivery of HIV-1 DNA constructs to infant chimpanzees

Mark L. Bagarazzi; Jean D. Boyer; M. Ali Javadian; Michael Chattergoon; Kesen Dang; Grace Kim; Jyoti Shah; Bin Wang; David B. Weiner

doi:10.1111/j.1600-0684.1997.tb00316.x

Safety and immunogenicity of intramuscular and intravaginal delivery of HIV-1 DNA constructs to infant chimpanzees

Mark L. Bagarazzi, Jean D. Boyer, M. Ali Javadian, Michael Chattergoon, Kesen Dang, Grace Kim, Jyoti Shah, Bin Wang, David B. Weiner

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Any global strategy for controlling the human immunodeficiency virus (HIV) epidemic is likely to rely heavily on immunization of infants and children. Given the well-documented differences in children's responses to traditional vaccines, we initiated this study to extend our findings on DNA vaccination of adult chimpanzees to immunologically immature infant chimpanzees. Our findings were consistent with our previous work in adults as we observed that the DNA vaccines used here were both well tolerated and immunogenic within weeks of the initial vaccination.

Original language	English (US)
Pages (from-to)	27-33
Number of pages	7
Journal	Journal of medical primatology
Volume	26
Issue number	1-2
DOIs	https://doi.org/10.1111/j.1600-0684.1997.tb00316.x
State	Published - 1997
Externally published	Yes

Keywords

Antibody
Gp120
Immature
Immunization
Mucosal
Pediatric
Plasmid
Pr55
Primate

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

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10.1111/j.1600-0684.1997.tb00316.x

Cite this

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AU - Bagarazzi, Mark L.

AU - Boyer, Jean D.

AU - Ali Javadian, M.

AU - Chattergoon, Michael

AU - Dang, Kesen

AU - Kim, Grace

AU - Shah, Jyoti

AU - Wang, Bin

AU - Weiner, David B.

PY - 1997

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AB - Any global strategy for controlling the human immunodeficiency virus (HIV) epidemic is likely to rely heavily on immunization of infants and children. Given the well-documented differences in children's responses to traditional vaccines, we initiated this study to extend our findings on DNA vaccination of adult chimpanzees to immunologically immature infant chimpanzees. Our findings were consistent with our previous work in adults as we observed that the DNA vaccines used here were both well tolerated and immunogenic within weeks of the initial vaccination.

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KW - Plasmid

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Safety and immunogenicity of intramuscular and intravaginal delivery of HIV-1 DNA constructs to infant chimpanzees

Abstract

Keywords

ASJC Scopus subject areas

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