Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery

Andrew T. Gabrielson; Logan Galansky; Tamir Sholklapper; Isabella Florissi; Chad Crigger; Kelly Harris; Nora Haney; Hiten D. Patel; Ming Hsien Wang; Charlotte Wu; John P. Gearhart; Heather N. Di Carlo

doi:10.1016/j.urology.2023.01.056

Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery

Andrew T. Gabrielson, Logan Galansky, Tamir Sholklapper, Isabella Florissi, Chad Crigger, Kelly Harris, Nora Haney, Hiten D. Patel, Ming Hsien Wang, Charlotte Wu, John P. Gearhart, Heather N. Di Carlo

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

This study evaluates the tolerability and efficacy of preoperative dorsal penile nerve block with Exparel plus bupivacaine hydrochloride in children>6 years old undergoing ambulatory urologic surgery. We demonstrate that the drug combination is well-tolerated, with appropriate analgesic efficacy in the recovery room as well as at 48-hour and 10-14 day follow-up periods. These preliminary data justify the need to perform a prospective, randomized trial comparing Exparel plus bupivacaine hydrochloride to other common local anesthetic regimens used in pediatric urologic surgery.

Original language	English (US)
Pages (from-to)	190-193
Number of pages	4
Journal	Urology
Volume	176
DOIs	https://doi.org/10.1016/j.urology.2023.01.056
State	Published - Jun 2023

ASJC Scopus subject areas

Urology

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10.1016/j.urology.2023.01.056

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Gabrielson, A. T., Galansky, L., Sholklapper, T., Florissi, I., Crigger, C., Harris, K., Haney, N., Patel, H. D., Wang, M. H., Wu, C., Gearhart, J. P., & Di Carlo, H. N. (2023). Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery. Urology, 176, 190-193. https://doi.org/10.1016/j.urology.2023.01.056

Gabrielson, AT, Galansky, L, Sholklapper, T, Florissi, I, Crigger, C, Harris, K, Haney, N, Patel, HD, Wang, MH , Wu, C , Gearhart, JP & Di Carlo, HN 2023, 'Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery', Urology, vol. 176, pp. 190-193. https://doi.org/10.1016/j.urology.2023.01.056

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title = "Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery",

abstract = "This study evaluates the tolerability and efficacy of preoperative dorsal penile nerve block with Exparel plus bupivacaine hydrochloride in children>6 years old undergoing ambulatory urologic surgery. We demonstrate that the drug combination is well-tolerated, with appropriate analgesic efficacy in the recovery room as well as at 48-hour and 10-14 day follow-up periods. These preliminary data justify the need to perform a prospective, randomized trial comparing Exparel plus bupivacaine hydrochloride to other common local anesthetic regimens used in pediatric urologic surgery.",

author = "Gabrielson, {Andrew T.} and Logan Galansky and Tamir Sholklapper and Isabella Florissi and Chad Crigger and Kelly Harris and Nora Haney and Patel, {Hiten D.} and Wang, {Ming Hsien} and Charlotte Wu and Gearhart, {John P.} and {Di Carlo}, {Heather N.}",

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year = "2023",

month = jun,

doi = "10.1016/j.urology.2023.01.056",

language = "English (US)",

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AU - Gabrielson, Andrew T.

AU - Galansky, Logan

AU - Sholklapper, Tamir

AU - Florissi, Isabella

AU - Crigger, Chad

AU - Harris, Kelly

AU - Haney, Nora

AU - Patel, Hiten D.

AU - Wang, Ming Hsien

AU - Wu, Charlotte

AU - Gearhart, John P.

AU - Di Carlo, Heather N.

PY - 2023/6

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N2 - This study evaluates the tolerability and efficacy of preoperative dorsal penile nerve block with Exparel plus bupivacaine hydrochloride in children>6 years old undergoing ambulatory urologic surgery. We demonstrate that the drug combination is well-tolerated, with appropriate analgesic efficacy in the recovery room as well as at 48-hour and 10-14 day follow-up periods. These preliminary data justify the need to perform a prospective, randomized trial comparing Exparel plus bupivacaine hydrochloride to other common local anesthetic regimens used in pediatric urologic surgery.

AB - This study evaluates the tolerability and efficacy of preoperative dorsal penile nerve block with Exparel plus bupivacaine hydrochloride in children>6 years old undergoing ambulatory urologic surgery. We demonstrate that the drug combination is well-tolerated, with appropriate analgesic efficacy in the recovery room as well as at 48-hour and 10-14 day follow-up periods. These preliminary data justify the need to perform a prospective, randomized trial comparing Exparel plus bupivacaine hydrochloride to other common local anesthetic regimens used in pediatric urologic surgery.

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Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery

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