Safety and efficacy of antiplatelet therapy in patients with intermediate coronary artery stenosis and deferred revascularization

David Hong, Seung Hun Lee, Jihye Heo, Doosup Shin, Juhee Cho, Eliseo Guallar, Hyun Sung Joh, Hyun Kuk Kim, Junho Ha, Ki Hong Choi, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo Yong Hahn, Seung Hyuk Choi, Hyeon Cheol Gwon, Danbee Kang, Joo Myung Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction and objectives: This study investigated the safety and efficacy of antiplatelet therapy in patients with intermediate coronary artery stenosis who underwent deferred revascularization due to their fractional flow reserve (FFR). Methods: A nationwide cohort study was conducted using the Korean National Health Insurance Service database. A total of 4657 patients with intermediate coronary artery stenosis who underwent deferred revascularization due to their FFR were identified from 2013 to 2020. FFR was indicated in patients with no prior evidence of myocardial ischemia and intermediate coronary artery stenosis (50%-70%) as determined by quantitative coronary angiography. Patients were classified according to whether antiplatelet therapy was initiated after the index procedure. The primary efficacy outcome was major adverse cardiac and cerebrovascular events (MACCE), a composite of all-cause death, myocardial infarction, unplanned revascularization, and stroke, during a 5-year follow-up period. The primary safety outcome was any gastrointestinal bleeding. Results: After propensity score matching, there were 1634 patients in the antiplatelet therapy group and 1634 in the nonantiplatelet therapy group. The risk of MACCE was similar between the 2 groups (24.8% vs 24.7%; adjusted HR, 0.97; 95%CI, 0.84-1.13; P = 0.745). The risk of gastrointestinal bleeding was higher in the antiplatelet therapy group than in the nonantiplatelet therapy group (2.2% vs 1.2%; aHR, 2.07; 95%CI, 1.08-4.00). These results were similar in subgroup analyses. Conclusions: In patients with intermediate coronary artery stenosis who underwent deferred revascularization due to their FFR, antiplatelet therapy may increase the risk of gastrointestinal bleeding without reducing the risk of future ischemic events.

Original languageEnglish (US)
JournalRevista Espanola de Cardiologia
DOIs
StateAccepted/In press - 2025
Externally publishedYes

Keywords

  • Antiplatelet therapy
  • Fractional flow reserve
  • Intermediate coronary artery stenosis
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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