Saccharomyces cerevisiae Yta7 regulates histone gene expression

Angeline Gradolatto, Richard S. Rogers, Heather Lavender, Sean D. Taverna, C. David Allis, John D. Aitchison, Alan J. Tackett

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


The Saccharomyces cerevisiae Yta7 protein is a component of a nucleosome bound protein complex that maintains distinct transcriptional zones of chromatin. We previously found that one protein copurifying with Yta7 is the yFACT member Spt16. Epistasis analyses revealed a link between Yta7, Spt16, and other previously identified members of the histone regulatory pathway. In concurrence, Yta7 was found to regulate histone gene transcription in a cell-cycle-dependent manner. Association at the histone gene loci appeared to occur through binding of the bromodomain-like region of Yta7 with the N-terminal tail of histone H3. Our work suggests a mechanism in which Yta7 is localized to chromatin to establish regions of transcriptional silencing, and that one facet of this cellular mechanism is to modulate transcription of histone genes.

Original languageEnglish (US)
Pages (from-to)291-304
Number of pages14
Issue number1
StatePublished - May 2008
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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