Saccharomyces cerevisiae polymerase ζ functions in mitochondria

Hengshan Zhang, Aditi Chatterjee, Keshav K. Singh

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


The MtArg8 reversion assay, which measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase ζ and Rev1 proteins participate in the mitochondrial DNA mutagenesis. Supporting this evidence, both polymerase ζ and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase ζ and Rev1 proteins function in the mitochondria.

Original languageEnglish (US)
Pages (from-to)2683-2688
Number of pages6
Issue number4
StatePublished - Apr 2006
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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