Saccharomyces cerevisiae polymerase ζ functions in mitochondria

Hengshan Zhang; Aditi Chatterjee; Keshav K. Singh

doi:10.1534/genetics.105.051029

Saccharomyces cerevisiae polymerase ζ functions in mitochondria

Hengshan Zhang, Aditi Chatterjee, Keshav K. Singh

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The MtArg8 reversion assay, which measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase ζ and Rev1 proteins participate in the mitochondrial DNA mutagenesis. Supporting this evidence, both polymerase ζ and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase ζ and Rev1 proteins function in the mitochondria.

Original language	English (US)
Pages (from-to)	2683-2688
Number of pages	6
Journal	Genetics
Volume	172
Issue number	4
DOIs	https://doi.org/10.1534/genetics.105.051029
State	Published - Apr 2006
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1534/genetics.105.051029

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title = "Saccharomyces cerevisiae polymerase ζ functions in mitochondria",

abstract = "The MtArg8 reversion assay, which measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase ζ and Rev1 proteins participate in the mitochondrial DNA mutagenesis. Supporting this evidence, both polymerase ζ and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase ζ and Rev1 proteins function in the mitochondria.",

author = "Hengshan Zhang and Aditi Chatterjee and Singh, {Keshav K.}",

year = "2006",

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AB - The MtArg8 reversion assay, which measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase ζ and Rev1 proteins participate in the mitochondrial DNA mutagenesis. Supporting this evidence, both polymerase ζ and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase ζ and Rev1 proteins function in the mitochondria.

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Saccharomyces cerevisiae polymerase ζ functions in mitochondria

Abstract

ASJC Scopus subject areas

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