S-nitrosylation: A radical way to protect the heart

Elizabeth Murphy, Mark Kohr, Junhui Sun, Tiffany Nguyen, Charles Steenbergen

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations


In this review, the role of S-nitrosylation (SNO) in cardioprotection will be discussed. This review will cover the methodology used to measure SNO levels, and the mechanisms by which SNO serves to modulate cell function and mediate protection. We will also consider whether SNO acts through many targets or whether there are a few key SNO proteins that mediate protection. Issues regarding the percentage of the total protein which is SNO and how this plays a role in the modulation of cell function will also be discussed. The role of nitric oxide synthase uncoupling in cardioprotection will also be addressed. This article is part of a Special Section entitled "Post-translational Modification.".

Original languageEnglish (US)
Pages (from-to)568-577
Number of pages10
JournalJournal of Molecular and Cellular Cardiology
Issue number3
StatePublished - Mar 2012


  • Cardioprotection
  • Ischemia
  • Nitric oxide
  • Proteomics
  • Redox
  • S-nitrosylation

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine


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