RXFP1 is targeted by complement C1q Tumor Necrosis Factor-related factor 8 (CTRP8) in brain cancer

Thatchawan Thanasupawat; Aleksandra Glogowska; Maxwell Burg; G. William Wong; Cuong Hoang-Vu; Sabine Hombach-Klonisch; Thomas Klonisch

doi:10.3389/fendo.2015.00127

RXFP1 is targeted by complement C1q Tumor Necrosis Factor-related factor 8 (CTRP8) in brain cancer

Thatchawan Thanasupawat
, Aleksandra Glogowska
, Maxwell Burg
, G. William Wong
, Cuong Hoang-Vu
, Sabine Hombach-Klonisch
, Thomas Klonisch

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The relaxin-like - RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/ Tumor Necrosis Factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor RXFP1 with functions in brain cancer. Here we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.

Original language	English (US)
Article number	127
Journal	Frontiers in Endocrinology
Volume	6
Issue number	JUL
DOIs	https://doi.org/10.3389/fendo.2015.00127
State	Published - 2015

Keywords

Brain tumor
C1q/TNF-related proteins
CTRP8
Cancer
RXFP1

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

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10.3389/fendo.2015.00127

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title = "RXFP1 is targeted by complement C1q Tumor Necrosis Factor-related factor 8 (CTRP8) in brain cancer",

abstract = "The relaxin-like - RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/ Tumor Necrosis Factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor RXFP1 with functions in brain cancer. Here we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.",

keywords = "Brain tumor, C1q/TNF-related proteins, CTRP8, Cancer, RXFP1",

author = "Thatchawan Thanasupawat and Aleksandra Glogowska and Maxwell Burg and Wong, \{G. William\} and Cuong Hoang-Vu and Sabine Hombach-Klonisch and Thomas Klonisch",

note = "Publisher Copyright: {\textcopyright} 2015 Thanasupawat, Glogowska, Burg, Wong, Hoang-vu,Hombach-klonisch and Klonisch.",

year = "2015",

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language = "English (US)",

volume = "6",

journal = "Frontiers in Endocrinology",

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T1 - RXFP1 is targeted by complement C1q Tumor Necrosis Factor-related factor 8 (CTRP8) in brain cancer

AU - Thanasupawat, Thatchawan

AU - Glogowska, Aleksandra

AU - Burg, Maxwell

AU - Wong, G. William

AU - Hoang-Vu, Cuong

AU - Hombach-Klonisch, Sabine

AU - Klonisch, Thomas

PY - 2015

Y1 - 2015

N2 - The relaxin-like - RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/ Tumor Necrosis Factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor RXFP1 with functions in brain cancer. Here we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.

AB - The relaxin-like - RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/ Tumor Necrosis Factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor RXFP1 with functions in brain cancer. Here we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.

KW - Brain tumor

KW - C1q/TNF-related proteins

KW - CTRP8

KW - Cancer

KW - RXFP1

UR - https://www.scopus.com/pages/publications/84938910751

UR - https://www.scopus.com/pages/publications/84938910751#tab=citedBy

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DO - 10.3389/fendo.2015.00127

M3 - Article

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AN - SCOPUS:84938910751

SN - 1664-2392

VL - 6

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

IS - JUL

M1 - 127

ER -

RXFP1 is targeted by complement C1q Tumor Necrosis Factor-related factor 8 (CTRP8) in brain cancer

Abstract

Keywords

ASJC Scopus subject areas

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