TY - JOUR
T1 - RXFP1 is targeted by complement C1q Tumor Necrosis Factor-related factor 8 (CTRP8) in brain cancer
AU - Thanasupawat, Thatchawan
AU - Glogowska, Aleksandra
AU - Burg, Maxwell
AU - Wong, G. William
AU - Hoang-Vu, Cuong
AU - Hombach-Klonisch, Sabine
AU - Klonisch, Thomas
N1 - Publisher Copyright:
© 2015 Thanasupawat, Glogowska, Burg, Wong, Hoang-vu,Hombach-klonisch and Klonisch.
PY - 2015
Y1 - 2015
N2 - The relaxin-like - RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/ Tumor Necrosis Factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor RXFP1 with functions in brain cancer. Here we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.
AB - The relaxin-like - RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/ Tumor Necrosis Factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor RXFP1 with functions in brain cancer. Here we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.
KW - Brain tumor
KW - C1q/TNF-related proteins
KW - CTRP8
KW - Cancer
KW - RXFP1
UR - http://www.scopus.com/inward/record.url?scp=84938910751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938910751&partnerID=8YFLogxK
U2 - 10.3389/fendo.2015.00127
DO - 10.3389/fendo.2015.00127
M3 - Article
C2 - 26322020
AN - SCOPUS:84938910751
SN - 1664-2392
VL - 6
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
IS - JUL
M1 - 127
ER -