Rubeosis Iridis and Glaucoma Associated with Sickle Cell Retinopathy: A Light and Electron Microscopic Study

Morton F. Goldberg; Mark O.M. Tso

doi:10.1016/S0161-6420(78)35587-1

Rubeosis Iridis and Glaucoma Associated with Sickle Cell Retinopathy: A Light and Electron Microscopic Study

Morton F. Goldberg, Mark O.M. Tso

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The ultrastructure of rubeosis iridis in sickle cell-hemoglobin C disease is described for the first time. Findings included open interendothelial cell junctions, intraendothelial cytoplasmic attenuations (fenestrations), and pericyte formation. The ultrastructural appearance of rubeosis iridis gives no clue to the underlying etiology and is similar to that reported in rubeosis associated with diabetes mellitus, central retinal vein occlusion, and uveitis. The electron microscopic findings explain the functional incompetence of rubeotic vessels that are manifested by transmural leakage of fluorescein.

Original language	English (US)
Pages (from-to)	1028-1041
Number of pages	14
Journal	Ophthalmology
Volume	85
Issue number	10
DOIs	https://doi.org/10.1016/S0161-6420(78)35587-1
State	Published - 1978
Externally published	Yes

Keywords

Sickle cell disease
central retinal artery occlusion
choroidal infarcts
diabetes
electron microscopy
endothelium
glaucoma
hypoxia
ischemia
pericytes
rubeosis iridis

ASJC Scopus subject areas

Ophthalmology

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10.1016/S0161-6420(78)35587-1

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@article{d5866d4cd624498e8ccaa87451b591aa,

title = "Rubeosis Iridis and Glaucoma Associated with Sickle Cell Retinopathy: A Light and Electron Microscopic Study",

abstract = "The ultrastructure of rubeosis iridis in sickle cell-hemoglobin C disease is described for the first time. Findings included open interendothelial cell junctions, intraendothelial cytoplasmic attenuations (fenestrations), and pericyte formation. The ultrastructural appearance of rubeosis iridis gives no clue to the underlying etiology and is similar to that reported in rubeosis associated with diabetes mellitus, central retinal vein occlusion, and uveitis. The electron microscopic findings explain the functional incompetence of rubeotic vessels that are manifested by transmural leakage of fluorescein.",

keywords = "Sickle cell disease, central retinal artery occlusion, choroidal infarcts, diabetes, electron microscopy, endothelium, glaucoma, hypoxia, ischemia, pericytes, rubeosis iridis",

author = "Goldberg, {Morton F.} and Tso, {Mark O.M.}",

note = "Funding Information: This study was supported in part by an unrestricted research grant from Research to Prevent Blindness, Inc, New York City; a research grant from the Illinois Society for the Prevention of Blindness, Chicago; grant iP 18HL 15168 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda; and Public Health Service grant No. 1903 from the National Eye Institute.",

year = "1978",

doi = "10.1016/S0161-6420(78)35587-1",

language = "English (US)",

volume = "85",

pages = "1028--1041",

journal = "Ophthalmology",

issn = "0161-6420",

publisher = "Elsevier Inc.",

number = "10",

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T1 - Rubeosis Iridis and Glaucoma Associated with Sickle Cell Retinopathy

T2 - A Light and Electron Microscopic Study

AU - Goldberg, Morton F.

AU - Tso, Mark O.M.

N1 - Funding Information: This study was supported in part by an unrestricted research grant from Research to Prevent Blindness, Inc, New York City; a research grant from the Illinois Society for the Prevention of Blindness, Chicago; grant iP 18HL 15168 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda; and Public Health Service grant No. 1903 from the National Eye Institute.

PY - 1978

Y1 - 1978

N2 - The ultrastructure of rubeosis iridis in sickle cell-hemoglobin C disease is described for the first time. Findings included open interendothelial cell junctions, intraendothelial cytoplasmic attenuations (fenestrations), and pericyte formation. The ultrastructural appearance of rubeosis iridis gives no clue to the underlying etiology and is similar to that reported in rubeosis associated with diabetes mellitus, central retinal vein occlusion, and uveitis. The electron microscopic findings explain the functional incompetence of rubeotic vessels that are manifested by transmural leakage of fluorescein.

AB - The ultrastructure of rubeosis iridis in sickle cell-hemoglobin C disease is described for the first time. Findings included open interendothelial cell junctions, intraendothelial cytoplasmic attenuations (fenestrations), and pericyte formation. The ultrastructural appearance of rubeosis iridis gives no clue to the underlying etiology and is similar to that reported in rubeosis associated with diabetes mellitus, central retinal vein occlusion, and uveitis. The electron microscopic findings explain the functional incompetence of rubeotic vessels that are manifested by transmural leakage of fluorescein.

KW - Sickle cell disease

KW - central retinal artery occlusion

KW - choroidal infarcts

KW - diabetes

KW - electron microscopy

KW - endothelium

KW - glaucoma

KW - hypoxia

KW - ischemia

KW - pericytes

KW - rubeosis iridis

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DO - 10.1016/S0161-6420(78)35587-1

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AN - SCOPUS:0018220516

SN - 0161-6420

VL - 85

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JO - Ophthalmology

JF - Ophthalmology

IS - 10

ER -

Rubeosis Iridis and Glaucoma Associated with Sickle Cell Retinopathy: A Light and Electron Microscopic Study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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