RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets

Corey A. Carter; Bryan T. Oronsky; Scott Z. Caroen; Jan J. Scicinski; Aiste Degesys; Michelle M. Kim; Arnold L. Oronsky; Harry Lybeck; Pedro Cabrales; Neil Oronsky; Tony Reid; Joseph Roswarski; Christina Brzezniak

doi:10.1159/000444631

RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets

Corey A. Carter, Bryan T. Oronsky, Scott Z. Caroen, Jan J. Scicinski, Aiste Degesys, Michelle M. Kim, Arnold L. Oronsky, Harry Lybeck, Pedro Cabrales, Neil Oronsky, Tony Reid, Joseph Roswarski, Christina Brzezniak

School of Medicine

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

RRx-001 is a pan-active, systemically nontoxic epigenetic inhibitor under investigation in advanced non-small cell lung cancer, small-cell lung cancer and high-grade neuroendocrine tumors in a Phase II clinical trial entitled TRIPLE THREAT (NCT02489903), which reexposes patients to previously effective but refractory platinum doublets after treatment with RRx-001. The purpose of this case study is first to report a partial response to carboplatin and etoposide in a patient with small-cell lung cancer pretreated with RRx-001, indicating episensitization or resensitization by epigenetic mechanisms, and second to discuss the literature related to small-cell lung cancer and episensitization.

Original language	English (US)
Pages (from-to)	171-176
Number of pages	6
Journal	Case Reports in Oncology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1159/000444631
State	Published - 2016

Keywords

Epigenetic
Episensitization
Platinum doublets
Resensitization
Resistance
Small-cell lung cancer

ASJC Scopus subject areas

Oncology

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10.1159/000444631

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Carter, C. A., Oronsky, B. T., Caroen, S. Z., Scicinski, J. J., Degesys, A., Kim, M. M., Oronsky, A. L., Lybeck, H., Cabrales, P., Oronsky, N., Reid, T., Roswarski, J., & Brzezniak, C. (2016). RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets. Case Reports in Oncology, 9(1), 171-176. https://doi.org/10.1159/000444631

Carter, CA, Oronsky, BT, Caroen, SZ, Scicinski, JJ, Degesys, A, Kim, MM, Oronsky, AL, Lybeck, H, Cabrales, P, Oronsky, N, Reid, T, Roswarski, J & Brzezniak, C 2016, 'RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets', Case Reports in Oncology, vol. 9, no. 1, pp. 171-176. https://doi.org/10.1159/000444631

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abstract = "RRx-001 is a pan-active, systemically nontoxic epigenetic inhibitor under investigation in advanced non-small cell lung cancer, small-cell lung cancer and high-grade neuroendocrine tumors in a Phase II clinical trial entitled TRIPLE THREAT (NCT02489903), which reexposes patients to previously effective but refractory platinum doublets after treatment with RRx-001. The purpose of this case study is first to report a partial response to carboplatin and etoposide in a patient with small-cell lung cancer pretreated with RRx-001, indicating episensitization or resensitization by epigenetic mechanisms, and second to discuss the literature related to small-cell lung cancer and episensitization.",

keywords = "Epigenetic, Episensitization, Platinum doublets, Resensitization, Resistance, Small-cell lung cancer",

author = "Carter, {Corey A.} and Oronsky, {Bryan T.} and Caroen, {Scott Z.} and Scicinski, {Jan J.} and Aiste Degesys and Kim, {Michelle M.} and Oronsky, {Arnold L.} and Harry Lybeck and Pedro Cabrales and Neil Oronsky and Tony Reid and Joseph Roswarski and Christina Brzezniak",

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RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets

Abstract

Keywords

ASJC Scopus subject areas

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