Rotavirus rna variation during chronic infection of immunocompromised children

Joseph Eiden, Genevieve A. Losonsky, John Johnson, Robert H. Yolken

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Polyacrylamide gel electrophoresis was per-formed on RNA from rotaviruses isolated from two immunocompromised patients with prolonged rotavirus diarrhea. Extensive variations were observed in the genomes of rotaviruses isolated from each patient during a 16-week period of their illness. An animal model of rotavirus infection was used to help evaluate the results found in our patients. Individual mouse rotavirus strains were found to be stable during serial passage, but individual animals could be coinfected with more than one viral strain. The changes found in the rotavirus RNA from our patients possibly represented reinfection by different viral strains. Appropriate precautions should be observed to prevent such reinfections in immunocompromised patients.

Original languageEnglish (US)
Pages (from-to)632-637
Number of pages6
JournalPediatric Infectious Disease
Issue number6
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)


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