TY - JOUR
T1 - Rosai-Dorfman disease presenting with widespread intracranial and spinal cord involvement
AU - Kidd, Desmond P.
AU - Revesz, Tamas
AU - Miller, Neil R.
PY - 2006/11
Y1 - 2006/11
N2 - Rosai-Dorfman disease is associated with a histiocytic infiltration of lymphoid tissue, but may also involve the orbit, nasopharynx, respiratory pathways, gastrointestinal tract, endocrine glands (particularly the thyroid), bone, and skin. Neurologic manifestations are rare, occurring in 4% of one series, and the diagnosis is often not made until pathology is available. Using data from two cases, we present the clinical manifestations, pathology, and treatment, and review the literature regarding the ocular and neurologic manifestations. Finally, we discuss the optimum management of this disorder.
AB - Rosai-Dorfman disease is associated with a histiocytic infiltration of lymphoid tissue, but may also involve the orbit, nasopharynx, respiratory pathways, gastrointestinal tract, endocrine glands (particularly the thyroid), bone, and skin. Neurologic manifestations are rare, occurring in 4% of one series, and the diagnosis is often not made until pathology is available. Using data from two cases, we present the clinical manifestations, pathology, and treatment, and review the literature regarding the ocular and neurologic manifestations. Finally, we discuss the optimum management of this disorder.
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U2 - 10.1212/01.wnl.0000242893.55416.8e
DO - 10.1212/01.wnl.0000242893.55416.8e
M3 - Review article
C2 - 17101885
AN - SCOPUS:33750974780
SN - 0028-3878
VL - 67
SP - 1551
EP - 1555
JO - Neurology
JF - Neurology
IS - 9
ER -