Roles of YAP/TAZ in ferroptosis

Suchitra Magesh; Danfeng Cai

doi:10.1016/j.tcb.2022.05.005

Roles of YAP/TAZ in ferroptosis

Suchitra Magesh, Danfeng Cai

Bloomberg School of Public Health

Research output: Contribution to journal › Short survey › peer-review

Abstract

Ferroptosis is a unique iron-dependent form of regulated cell death. Recently, researchers found that ferroptosis was sensitive to cell density, regulated by Hippo signaling. This article summarizes the roles of the Hippo pathway effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in ferroptosis and the therapeutic potential of activating ferroptosis in cancer.

Original language	English (US)
Pages (from-to)	729-732
Number of pages	4
Journal	Trends in Cell Biology
Volume	32
Issue number	9
DOIs	https://doi.org/10.1016/j.tcb.2022.05.005
State	Published - Sep 2022

Keywords

Hippo pathway
TAZ
YAP
ferroptosis

ASJC Scopus subject areas

Cell Biology

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10.1016/j.tcb.2022.05.005

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title = "Roles of YAP/TAZ in ferroptosis",

abstract = "Ferroptosis is a unique iron-dependent form of regulated cell death. Recently, researchers found that ferroptosis was sensitive to cell density, regulated by Hippo signaling. This article summarizes the roles of the Hippo pathway effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in ferroptosis and the therapeutic potential of activating ferroptosis in cancer.",

keywords = "Hippo pathway, TAZ, YAP, ferroptosis",

author = "Suchitra Magesh and Danfeng Cai",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = sep,

doi = "10.1016/j.tcb.2022.05.005",

language = "English (US)",

volume = "32",

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AU - Magesh, Suchitra

AU - Cai, Danfeng

PY - 2022/9

Y1 - 2022/9

N2 - Ferroptosis is a unique iron-dependent form of regulated cell death. Recently, researchers found that ferroptosis was sensitive to cell density, regulated by Hippo signaling. This article summarizes the roles of the Hippo pathway effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in ferroptosis and the therapeutic potential of activating ferroptosis in cancer.

AB - Ferroptosis is a unique iron-dependent form of regulated cell death. Recently, researchers found that ferroptosis was sensitive to cell density, regulated by Hippo signaling. This article summarizes the roles of the Hippo pathway effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in ferroptosis and the therapeutic potential of activating ferroptosis in cancer.

KW - Hippo pathway

KW - TAZ

KW - YAP

KW - ferroptosis

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U2 - 10.1016/j.tcb.2022.05.005

DO - 10.1016/j.tcb.2022.05.005

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JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 9

ER -

Roles of YAP/TAZ in ferroptosis

Abstract

Keywords

ASJC Scopus subject areas

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