Roles of nuclear factor κB in neuronal survival and plasticity

Mark P. Mattson, Carsten Culmsee, Zaifang Yu, Simonetta Camandola

Research output: Contribution to journalArticlepeer-review

421 Scopus citations


The transcription factor nuclear factor κB (NF-κB) is moving to the forefront of the fields of apoptosis and neuronal plasticity because of recent findings showing that activation of NF-κB prevents neuronal apoptosis in various cell culture and in vivo models and because NF-κB is activated in association with synaptic plasticity. Activation of NF-κB was first shown to mediate antiapoptotic actions of tumor necrosis factor in cultured neurons and was subsequently shown to prevent death of various nonneuronal cells. NF- κB is activated by several cytokines and neurotrophic factors and in response to various cell stressors. Oxidative stress and elevation of intracellular calcium levels are particularly important inducers of NF-κB activation. Activation of NF-κB can interrupt apoptotic biochemical cascades at relatively early steps, before mitochondrial dysfunction and oxyradical production. Gene targets for NF-κB that may mediate its antiapoptotic actions include the antioxidant enzyme manganese superoxide dismutase, members of the inhibitor of apoptosis family of proteins, and the calcium- binding protein calbindin D28k. NF-κB is activated by synaptic activity and may play important roles in the process of learning and memory. The available data identify NF-κB as an important regulator of evolutionarily conserved biochemical and molecular cascades designed to prevent cell death and promote neuronal plasticity. Because NF-κB may play roles in a range of neurological disorders that involve neuronal degeneration and/or perturbed synaptic function, pharmacological and genetic manipulations of NF-κB signaling are being developed that may prove valuable in treating disorders ranging from Alzheimer's disease to schizophrenia.

Original languageEnglish (US)
Pages (from-to)443-456
Number of pages14
JournalJournal of Neurochemistry
Issue number2
StatePublished - 2000
Externally publishedYes


  • Apoptosis
  • Excitotoxicity
  • Hippocampus
  • Long-term potentiation
  • Neurotrophic factor
  • Oxidative stress
  • Transcription factor
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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