Roles for biological membranes in regulating human immunodeficiency virus replication and progress in the development of HIV therapeutics that target lipid metabolism

Norman J. Haughey; Luis B. Tovar-Y-Romo; Veera Venkata Ratnam Bandaru

doi:10.1007/s11481-011-9274-7

Roles for biological membranes in regulating human immunodeficiency virus replication and progress in the development of HIV therapeutics that target lipid metabolism

Norman J. Haughey, Luis B. Tovar-Y-Romo, Veera Venkata Ratnam Bandaru

School of Medicine

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Infection by the human immunodeficiency virus (HIV) involves a number of important interactions with lipid components in host membranes that regulate binding, fusion, internalization, and viral assembly. Available data suggests that HIV actively modifies the sphingolipid content of cellular membranes to create focal environments that are favorable for infection. In this review, we summarize the roles that membrane lipids play in HIV infection and discuss the current status of therapeutics that attempt to modify biological membranes to inhibit HIV.

Original language	English (US)
Pages (from-to)	284-295
Number of pages	12
Journal	Journal of Neuroimmune Pharmacology
Volume	6
Issue number	2
DOIs	https://doi.org/10.1007/s11481-011-9274-7
State	Published - Jun 2011

Keywords

HIV
Lipid raft
Sphingolipid
Therapeutics

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Immunology and Allergy
Immunology
Pharmacology

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10.1007/s11481-011-9274-7

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Roles for biological membranes in regulating human immunodeficiency virus replication and progress in the development of HIV therapeutics that target lipid metabolism. / Haughey, Norman J.; Tovar-Y-Romo, Luis B.; Bandaru, Veera Venkata Ratnam.
In: Journal of Neuroimmune Pharmacology, Vol. 6, No. 2, 06.2011, p. 284-295.

Research output: Contribution to journal › Review article › peer-review

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abstract = "Infection by the human immunodeficiency virus (HIV) involves a number of important interactions with lipid components in host membranes that regulate binding, fusion, internalization, and viral assembly. Available data suggests that HIV actively modifies the sphingolipid content of cellular membranes to create focal environments that are favorable for infection. In this review, we summarize the roles that membrane lipids play in HIV infection and discuss the current status of therapeutics that attempt to modify biological membranes to inhibit HIV.",

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N2 - Infection by the human immunodeficiency virus (HIV) involves a number of important interactions with lipid components in host membranes that regulate binding, fusion, internalization, and viral assembly. Available data suggests that HIV actively modifies the sphingolipid content of cellular membranes to create focal environments that are favorable for infection. In this review, we summarize the roles that membrane lipids play in HIV infection and discuss the current status of therapeutics that attempt to modify biological membranes to inhibit HIV.

AB - Infection by the human immunodeficiency virus (HIV) involves a number of important interactions with lipid components in host membranes that regulate binding, fusion, internalization, and viral assembly. Available data suggests that HIV actively modifies the sphingolipid content of cellular membranes to create focal environments that are favorable for infection. In this review, we summarize the roles that membrane lipids play in HIV infection and discuss the current status of therapeutics that attempt to modify biological membranes to inhibit HIV.

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Roles for biological membranes in regulating human immunodeficiency virus replication and progress in the development of HIV therapeutics that target lipid metabolism

Abstract

Keywords

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