Role of therapeutic plasmapheresis in the acute Guillain-Barré syndrome

G. M. McKhann, J. W. Griffin, D. R. Cornblath, S. A. Quaskey, E. D. Mellits

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Plasmapheresis modifies the course of the acute Guillain-Barré syndrome (GBS) in terms of time-related parameters such as time on a respirator or time to achieve a specific area of improvement at specific times after onset of the illness such as at 1 month and at 6 months. Certain factors are associated with poorer outcomes in acute GBS. These include amplitude of compound muscle axon potentials on stimulating distally, time of onset of disease of 7 days or less, need for ventilatory support, and older age. Plasmapheresis, the only variable that the physician can influence, has a beneficial effect over and above all these factors.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalJournal of Neuroimmunology
Issue number2-3
StatePublished - Dec 1988


  • Guillain-Barré syndrome
  • Plasmapheresis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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