Role of the parasympathetic system in antigen induced bronchospasm

R. R. Rosenthal, P. S. Norman, W. R. Summer, S. Permutt

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Human subjects, sensitive to ragweed, inhaled aerosols of increasing concentrations of ragweed pollen extract in the presence and absence of pretreatment with inhaled atropine. The cumulative dose of antigen required for a 35% decrease in airways conductance was termed PD35. Atropine, 1.2 or 5 mg, increased airways conductance before antigenic challenge but did not alter significantly the PD35 for ragweed extract, although these doses of atropine inhibited airways responses to inhaled methacholine chloride and citric acid. We conclude that the cholinergic nervous system plays a modulating role in bronchomotor tone and responses to irritants, but that parasympathetic reflexes are not invariably a major component of human bronchial responses to inhaled allergen.

Original languageEnglish (US)
Pages (from-to)600-606
Number of pages7
Issue number4
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Physiology
  • Endocrinology


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