Role of polycomb proteins in regulating HSV-1 latency

Zachary Watson; Adit Dhummakupt; Harald Messer; Dane Phelan; David Bloom

doi:10.3390/v5071740

Role of polycomb proteins in regulating HSV-1 latency

Zachary Watson, Adit Dhummakupt, Harald Messer, Dane Phelan, David Bloom

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition.

Original language	English (US)
Pages (from-to)	1740-1757
Number of pages	18
Journal	Viruses
Volume	5
Issue number	7
DOIs	https://doi.org/10.3390/v5071740
State	Published - Jul 15 2013
Externally published	Yes

Keywords

HSV
Herpes
Heterochromatin
Latency
PRC
Polycomb
Reactivation

ASJC Scopus subject areas

Infectious Diseases
Virology

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10.3390/v5071740

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title = "Role of polycomb proteins in regulating HSV-1 latency",

abstract = "Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition.",

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author = "Zachary Watson and Adit Dhummakupt and Harald Messer and Dane Phelan and David Bloom",

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T1 - Role of polycomb proteins in regulating HSV-1 latency

AU - Watson, Zachary

AU - Dhummakupt, Adit

AU - Messer, Harald

AU - Phelan, Dane

AU - Bloom, David

PY - 2013/7/15

Y1 - 2013/7/15

N2 - Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition.

AB - Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition.

KW - HSV

KW - Herpes

KW - Heterochromatin

KW - Latency

KW - PRC

KW - Polycomb

KW - Reactivation

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SP - 1740

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JO - Viruses

JF - Viruses

IS - 7

ER -

Role of polycomb proteins in regulating HSV-1 latency

Abstract

Keywords

ASJC Scopus subject areas

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