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Role of phase 2 enzyme induction in chemoprotection by dithiolethiones
Mi Kyoung Kwak
, Patricia A. Egner
, Patrick M. Dolan
, Minerva Ramos-Gomez
,
John D. Groopman
, Ken Itoh
, Masayuki Yamamoto
,
Thomas W. Kensler
Bloomberg School of Public Health
Research output
:
Contribution to journal
›
Article
›
peer-review
212
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Keyphrases
Dithiolethiones
100%
Oltipraz
100%
Phase II Enzymes
100%
Chemoprotection
100%
Enzyme Induction
100%
Aflatoxin
66%
Chemopreventive
50%
1,2-Dithiole-3-thiones
50%
Carcinogen
50%
Aflatoxin B1 (AFB1)
50%
Chemoprevention
50%
Metabolism
33%
Nuclear Factor Erythroid 2-related Factor 2 (Nrf2)
33%
Transcription Factor
16%
Rodents
16%
High Risk
16%
Attenuation
16%
Placebo-controlled
16%
Oxidative Stress
16%
Transcriptional Activation
16%
Glutathione S-transferase
16%
Mechanistic Studies
16%
Oncogenesis
16%
Quinone Reductase
16%
Mutagenesis
16%
Multiple Organs
16%
Glutathione Conjugates
16%
High-risk Population
16%
Drug Administration
16%
Gene-deficient Mice
16%
Rodent Models
16%
UDP-glucuronosyltransferase
16%
Antioxidant Response Element
16%
Sulforaphane
16%
Aflatoxin M1 (AFM1)
16%
Liver Cancer
16%
Nuclear Accumulation
16%
Extended Period
16%
Protection Mechanism
16%
Double-blind Clinical Trial
16%
Detoxication
16%
Qidong
16%
Oxidative Metabolites
16%
Hepatocarcinogenesis
16%
Thiocyanate
16%
Intermediate Endpoint
16%
Terpenoids
16%
Mercapturic Acids
16%
PR China
16%
At-risk Populations
16%
Basal Expression
16%
Long-term Intervention
16%
Antischistosomal Drug
16%
Pharmacology, Toxicology and Pharmaceutical Science
Oltipraz
100%
Enzyme Induction
100%
Aflatoxin
66%
Enzymes
66%
Carcinogen
50%
Aflatoxin B1
50%
1,2 Dithiole 3 Thione Derivative
50%
Chemopreventive Agents
33%
Glutathione
33%
Transcription Factor Nrf2
33%
Placebo
16%
Clinical Trial
16%
Antioxidant
16%
Reduced Nicotinamide Adenine Dinucleotide (Phosphate) Dehydrogenase (Quinone)
16%
Transferase
16%
Carcinogenesis
16%
Detoxication
16%
Glucuronosyltransferase
16%
Sulforaphane
16%
Liver Cancer
16%
Uridine Diphosphate
16%
Acetylcysteine
16%
Mutagenesis
16%
Drug Administration
16%
Isothiocyanate
16%
Liver Carcinogenesis
16%
Terpenoid
16%
Antischistosomal Agent
16%