Role of nitric oxide scavenging in peripheral vasoconstrictor response to bovine ββ crosslinked hemoglobin

J. A. Ulatowski; R. C. Koehler; T. Nishikawa; R. J. Traystman; E. Bucci

Role of nitric oxide scavenging in peripheral vasoconstrictor response to bovine ββ crosslinked hemoglobin

J. A. Ulatowski, R. C. Koehler, T. Nishikawa, R. J. Traystman, E. Bucci

School of Medicine

Research output: Contribution to journal › Conference article › peer-review

Abstract

Using pentobarbital cats, the authors tested whether administration of the nitrogen oxide (NO) synthase inhibitor, L-nitro-L-arginine methyl ester (L-NAME), produced peripheral vasoconstriction after isovolemic exchange transfusion with hemoglobin (n = 8) to the same extent as occurs with L-NAME infusion in time controls (n = 8), and in controls matched for reduced hematocrit (17%) with albumin transfusion (n = 8). Hemoglobin exchange transfusion resulted in an increase in mean arterial pressure and there was no further increase after L-NAME. The lack of intestinal and renal vasoconstriction to L-NAME after hemoglobin transfusion is best explained by hemoglobin scavenging of NO prior to NO synthase inhibition.

Original language	English (US)
Pages (from-to)	A173
Journal	Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume	22
Issue number	5
State	Published - Nov 1 1994
Event	Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA Duration: Jul 24 1994 → Jul 27 1994

ASJC Scopus subject areas

Biotechnology
Biomedical Engineering

Cite this

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title = "Role of nitric oxide scavenging in peripheral vasoconstrictor response to bovine ββ crosslinked hemoglobin",

abstract = "Using pentobarbital cats, the authors tested whether administration of the nitrogen oxide (NO) synthase inhibitor, L-nitro-L-arginine methyl ester (L-NAME), produced peripheral vasoconstriction after isovolemic exchange transfusion with hemoglobin (n = 8) to the same extent as occurs with L-NAME infusion in time controls (n = 8), and in controls matched for reduced hematocrit (17%) with albumin transfusion (n = 8). Hemoglobin exchange transfusion resulted in an increase in mean arterial pressure and there was no further increase after L-NAME. The lack of intestinal and renal vasoconstriction to L-NAME after hemoglobin transfusion is best explained by hemoglobin scavenging of NO prior to NO synthase inhibition.",

author = "Ulatowski, {J. A.} and Koehler, {R. C.} and T. Nishikawa and Traystman, {R. J.} and E. Bucci",

year = "1994",

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TY - JOUR

T1 - Role of nitric oxide scavenging in peripheral vasoconstrictor response to bovine ββ crosslinked hemoglobin

AU - Ulatowski, J. A.

AU - Koehler, R. C.

AU - Nishikawa, T.

AU - Traystman, R. J.

AU - Bucci, E.

PY - 1994/11/1

Y1 - 1994/11/1

N2 - Using pentobarbital cats, the authors tested whether administration of the nitrogen oxide (NO) synthase inhibitor, L-nitro-L-arginine methyl ester (L-NAME), produced peripheral vasoconstriction after isovolemic exchange transfusion with hemoglobin (n = 8) to the same extent as occurs with L-NAME infusion in time controls (n = 8), and in controls matched for reduced hematocrit (17%) with albumin transfusion (n = 8). Hemoglobin exchange transfusion resulted in an increase in mean arterial pressure and there was no further increase after L-NAME. The lack of intestinal and renal vasoconstriction to L-NAME after hemoglobin transfusion is best explained by hemoglobin scavenging of NO prior to NO synthase inhibition.

AB - Using pentobarbital cats, the authors tested whether administration of the nitrogen oxide (NO) synthase inhibitor, L-nitro-L-arginine methyl ester (L-NAME), produced peripheral vasoconstriction after isovolemic exchange transfusion with hemoglobin (n = 8) to the same extent as occurs with L-NAME infusion in time controls (n = 8), and in controls matched for reduced hematocrit (17%) with albumin transfusion (n = 8). Hemoglobin exchange transfusion resulted in an increase in mean arterial pressure and there was no further increase after L-NAME. The lack of intestinal and renal vasoconstriction to L-NAME after hemoglobin transfusion is best explained by hemoglobin scavenging of NO prior to NO synthase inhibition.

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M3 - Conference article

AN - SCOPUS:17044460873

SN - 1073-1199

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JF - Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

IS - 5

T2 - Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI)

Y2 - 24 July 1994 through 27 July 1994

ER -

Role of nitric oxide scavenging in peripheral vasoconstrictor response to bovine ββ crosslinked hemoglobin

Abstract

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