Using pentobarbital cats, the authors tested whether administration of the nitrogen oxide (NO) synthase inhibitor, L-nitro-L-arginine methyl ester (L-NAME), produced peripheral vasoconstriction after isovolemic exchange transfusion with hemoglobin (n = 8) to the same extent as occurs with L-NAME infusion in time controls (n = 8), and in controls matched for reduced hematocrit (17%) with albumin transfusion (n = 8). Hemoglobin exchange transfusion resulted in an increase in mean arterial pressure and there was no further increase after L-NAME. The lack of intestinal and renal vasoconstriction to L-NAME after hemoglobin transfusion is best explained by hemoglobin scavenging of NO prior to NO synthase inhibition.
|Original language||English (US)|
|Journal||Artificial Cells, Blood Substitutes, and Immobilization Biotechnology|
|State||Published - Nov 1 1994|
|Event||Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA|
Duration: Jul 24 1994 → Jul 27 1994
ASJC Scopus subject areas
- Biomedical Engineering