Role of neuromodulation and optogenetic manipulation in pain treatment

Sufang Liu, Changsheng Li, Ying Xing, Yanqing Wang, Feng Tao

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Neuromodulation, including invasive and non-invasive stimulation, has been used to treat intractable chronic pain. However, the mechanisms by which neuromodulation produces antinociceptive effect still remain uncertain. Optogenetic manipulation, a recently developed novel approach, has already proven its value to clinicians by providing new insights into mechanisms of current clinical neuromodulation methods as well as pathophysiology of nervous system diseases at the circuit level. Here, we discuss the principles of two neuromodulation methods (deep brain stimulation and motor cortex stimulation) and their applications in pain treatment. More important, we summarize the new information from recent studies regarding optogenetic manipulation in neuroscience research and its potential utility in pain study.

Original languageEnglish (US)
Pages (from-to)654-661
Number of pages8
JournalCurrent Neuropharmacology
Issue number6
StatePublished - Aug 1 2016


  • Brain stimulation
  • Neuromodulation
  • Optogenetic manipulation
  • Pain

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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