TY - JOUR
T1 - Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury
AU - Jeon, Sangmin
AU - Jha, Mithilesh Kumar
AU - Ock, Jiyeon
AU - Seo, Jungwan
AU - Jin, Myungwon
AU - Cho, Heejung
AU - Lee, Won Ha
AU - Suk, Kyoungho
PY - 2013/8/16
Y1 - 2013/8/16
N2 - Background: In the central nervous system, the role of LCN2 as a chemokine inducer has been previously reported. Results: Peripheral nerve injury increased LCN2 expression. Lcn2 deficiency attenuated pain hypersensitivity, microglial activation, and chemokine production. Chemokine expression and pain behavior were induced by LCN2. Conclusion: The LCN2-chemokine axis plays a critical role in the pathogenesis of neuropathic pain. Significance: LCN2 can be targeted for treatment of neuropathic pain.
AB - Background: In the central nervous system, the role of LCN2 as a chemokine inducer has been previously reported. Results: Peripheral nerve injury increased LCN2 expression. Lcn2 deficiency attenuated pain hypersensitivity, microglial activation, and chemokine production. Chemokine expression and pain behavior were induced by LCN2. Conclusion: The LCN2-chemokine axis plays a critical role in the pathogenesis of neuropathic pain. Significance: LCN2 can be targeted for treatment of neuropathic pain.
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U2 - 10.1074/jbc.M113.454140
DO - 10.1074/jbc.M113.454140
M3 - Article
C2 - 23836894
AN - SCOPUS:84882412414
SN - 0021-9258
VL - 288
SP - 24116
EP - 24127
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 33
ER -