TY - JOUR
T1 - Role of Late-Life Depression in the Association of Subclinical Cardiovascular Disease With All-Cause Mortality
T2 - Cardiovascular Health Study
AU - Armstrong, Nicole M.
AU - Carlson, Michelle C.
AU - Xue, Qian Li
AU - Schrack, Jennifer
AU - Carnethon, Mercedes R.
AU - Chaves, Paulo H.M.
AU - Gross, Alden L.
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: N.M.A. was supported by fellowship from the Epidemiology and Biostatistics of Aging Training Grant (5T32AG000247). This research was supported by contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, and grants U01HL080295 and U01HL130114 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided by R01AG023629 from the National Institute on Aging (NIA). A full list of principal Cardiovascular Health Study (CHS) investigators and institutions can be found at CHS-NHLBI.org. The sponsor did not play any direct role in the design, methods, subject recruitment, data collections, analysis, and preparation of the article.
Publisher Copyright:
© The Author(s) 2017.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Objectives: To evaluate whether late-life depression mediates the association of subclinical cardiovascular disease (CVD) with all-cause mortality. Method: Using data from 3,473 Cardiovascular Health Study participants, the Cox proportional hazards model was used to examine the direct and indirect (via late-life depression) effects of the association between baseline subclinical CVD and all-cause mortality with weights derived from multivariable logistic regression of late-life depression on subclinical CVD. Results: Subclinical CVD led to a higher risk of all-cause mortality (hazard ratio [HR] = 1.51, 95% confidence interval, [CI] = [1.42, 1.94]). Total effect of subclinical CVD on all-cause mortality was decomposed into direct (HR = 1.41, 95% CI = [1.37, 1.58]) and indirect (HR = 1.07, 95% CI = [1.01, 1.23]) effects; 16.3% of the total effect of subclinical CVD on all-cause mortality was mediated by late-life depression. Discussion: Late-life depression accounts for little, if any, of the association between subclinical CVD, a risk factor of all-cause mortality, and all-cause mortality.
AB - Objectives: To evaluate whether late-life depression mediates the association of subclinical cardiovascular disease (CVD) with all-cause mortality. Method: Using data from 3,473 Cardiovascular Health Study participants, the Cox proportional hazards model was used to examine the direct and indirect (via late-life depression) effects of the association between baseline subclinical CVD and all-cause mortality with weights derived from multivariable logistic regression of late-life depression on subclinical CVD. Results: Subclinical CVD led to a higher risk of all-cause mortality (hazard ratio [HR] = 1.51, 95% confidence interval, [CI] = [1.42, 1.94]). Total effect of subclinical CVD on all-cause mortality was decomposed into direct (HR = 1.41, 95% CI = [1.37, 1.58]) and indirect (HR = 1.07, 95% CI = [1.01, 1.23]) effects; 16.3% of the total effect of subclinical CVD on all-cause mortality was mediated by late-life depression. Discussion: Late-life depression accounts for little, if any, of the association between subclinical CVD, a risk factor of all-cause mortality, and all-cause mortality.
KW - depression
KW - mortality
KW - subclinical cardiovascular disease
UR - http://www.scopus.com/inward/record.url?scp=85063213753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063213753&partnerID=8YFLogxK
U2 - 10.1177/0898264317744921
DO - 10.1177/0898264317744921
M3 - Article
C2 - 29254423
AN - SCOPUS:85063213753
SN - 0898-2643
VL - 31
SP - 652
EP - 666
JO - Journal of Aging and Health
JF - Journal of Aging and Health
IS - 4
ER -