TY - JOUR
T1 - Role of Environmental Air Pollution in Chronic Rhinosinusitis
AU - Leland, Evelyn M.
AU - Zhang, Zhenyu
AU - Kelly, Kathleen M.
AU - Ramanathan, Murugappan
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/8
Y1 - 2021/8
N2 - Purpose of Review: Chronic rhinosinusitis (CRS) is a highly prevalent disease with large social and financial burdens. The pathophysiology is multifactorial. Environmental pollutants have been suggested to play a role in the inflammatory component of the disease process. Recent Findings: Recent work has focused on exposure to various pollutants, primarily particulate matter (PM). Exposure to environmental pollutants leads to upregulation of inflammatory markers and ciliary dysfunction at the cellular level. Mouse models suggest a role for epithelial barrier dysfunction contributing to inflammatory changes after pollutant exposure. Clinical studies support the role of pollutants contributing to disease severity in certain populations, but the role in CRS incidence or prevalence is less clear. Research is limited by the retrospective nature of most studies. Summary: This review focuses on recent advancements in our understanding of the impact of environmental pollutants in CRS, limitations of the available data, and potential opportunities for future studies.
AB - Purpose of Review: Chronic rhinosinusitis (CRS) is a highly prevalent disease with large social and financial burdens. The pathophysiology is multifactorial. Environmental pollutants have been suggested to play a role in the inflammatory component of the disease process. Recent Findings: Recent work has focused on exposure to various pollutants, primarily particulate matter (PM). Exposure to environmental pollutants leads to upregulation of inflammatory markers and ciliary dysfunction at the cellular level. Mouse models suggest a role for epithelial barrier dysfunction contributing to inflammatory changes after pollutant exposure. Clinical studies support the role of pollutants contributing to disease severity in certain populations, but the role in CRS incidence or prevalence is less clear. Research is limited by the retrospective nature of most studies. Summary: This review focuses on recent advancements in our understanding of the impact of environmental pollutants in CRS, limitations of the available data, and potential opportunities for future studies.
KW - Air pollution
KW - Chronic rhinosinusitis
KW - Environmental exposure
KW - Environmental pollutants
KW - Pollution
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U2 - 10.1007/s11882-021-01019-6
DO - 10.1007/s11882-021-01019-6
M3 - Review article
C2 - 34499234
AN - SCOPUS:85114673873
SN - 1529-7322
VL - 21
JO - Current allergy and asthma reports
JF - Current allergy and asthma reports
IS - 8
M1 - 42
ER -