Role of endothelin in the exercise intolerance of chronic heart failure

Henry Krum, Rochelle Goldsmith, Michelle Wilshire-Clement, Myron Miller, Milton Packer

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


In conclusion, plasma levels of the endothelialderived vasoconstrictor endothelin-1 (but not those of other neurohormonal vasoconstrictor factors), measured during exercise correlated closely with objective variables of exercise capacity in patients with heart failure. These findings suggest that endothelin-1 may contribute to exercise intolerance in patients with heart failure, perhaps by limiting the ability of the peripheral vasculature to dilate during exercise.

Original languageEnglish (US)
Pages (from-to)1282-1283
Number of pages2
JournalThe American journal of cardiology
Issue number17
StatePublished - Jun 15 1995
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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