Role of direct oral anticoagulants in the management of anticoagulation

Rajiv Thakkar, Suman W. Rathbun, Scott M. Wright

Research output: Contribution to journalReview articlepeer-review


For decades, vitamin K antagonists (VKAs) have been the oral treatment of choice for many thromboembolic conditions. The limitations of VKAs include the need for monitoring through blood testing, drug interactions, and narrow therapeutic windows. These shortcomings have led to the development of direct oral anticoagulants. These new oral agents act on specific targets in the coagulation cascade (eg, factor Xa, thrombin) and negate some of the shortcomings of VKAs. This article reviews the roles of dabigatran, rivaroxaban, apixaban, and edoxaban in stroke prevention in nonvalvular atrial fibrillation, for prevention of venous thromboembolism after orthopedic surgery, and in the treatment of venous thromboembolism. Direct oral anticoagulants are at least as efficacious and safe as traditional anticoagulation therapy.

Original languageEnglish (US)
Pages (from-to)293-299
Number of pages7
JournalSouthern Medical Journal
Issue number4
StatePublished - Apr 1 2017


  • Anticoagulation
  • direct oral anticoagulants
  • oral anticoagulants
  • venous thromboembolism

ASJC Scopus subject areas

  • Medicine(all)


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