Role of complement in viral infections: Participation of terminal complement components (C5 to C9) in recovery of mice from Sindbis virus infection

R. L. Hirsch; Diane Griffin; J. A. Winkelstein

Role of complement in viral infections: Participation of terminal complement components (C5 to C9) in recovery of mice from Sindbis virus infection

R. L. Hirsch, Diane Griffin, J. A. Winkelstein

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The pathogenesis of Sindbis virus infection was studied in congenic mice with normal levels of the fifth component of complement (C5) and in mice deficient in C5. Mice deficient in C5 had a higher mortality rate than mice with normal levels of C5 as well as impaired clearance of virus from their brains and feet.

Original language	English (US)
Pages (from-to)	899-901
Number of pages	3
Journal	Infection and immunity
Volume	30
Issue number	3
State	Published - 1980

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

Cite this

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title = "Role of complement in viral infections: Participation of terminal complement components (C5 to C9) in recovery of mice from Sindbis virus infection",

abstract = "The pathogenesis of Sindbis virus infection was studied in congenic mice with normal levels of the fifth component of complement (C5) and in mice deficient in C5. Mice deficient in C5 had a higher mortality rate than mice with normal levels of C5 as well as impaired clearance of virus from their brains and feet.",

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AU - Winkelstein, J. A.

PY - 1980

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AB - The pathogenesis of Sindbis virus infection was studied in congenic mice with normal levels of the fifth component of complement (C5) and in mice deficient in C5. Mice deficient in C5 had a higher mortality rate than mice with normal levels of C5 as well as impaired clearance of virus from their brains and feet.

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Role of complement in viral infections: Participation of terminal complement components (C5 to C9) in recovery of mice from Sindbis virus infection

Abstract

ASJC Scopus subject areas

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