Abstract
Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal and distal targets of Btk action.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 534-540 |
| Number of pages | 7 |
| Journal | Current Opinion in Immunology |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1997 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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