Role of Brain Imaging in the Prediction of Intracerebral Hemorrhage Following Endovascular Therapy for Acute Stroke

Pierre Seners, Anke Wouters, Benjamin Maier, William Boisseau, Benjamin Gory, Jeremy J. Heit, Christophe Cognard, Mikael Mazighi, Brice Gaudilliere, Robin Lemmens, Greg Zaharchuk, Gregory W. Albers, Richard Leigh, Jean Marc Olivot

Research output: Contribution to journalReview articlepeer-review


Currently most acute ischemic stroke patients presenting with a large vessel occlusion are treated with endovascular therapy (EVT), which results in high rates of successful recanalization. Despite this success, more than half of EVT-treated patients are significantly disabled 3 months later partly due to the occurrence of post-EVT intracerebral hemorrhage. Predicting post-EVT intracerebral hemorrhage is important for individualizing treatment strategies in clinical practice (eg, safe initiation of early antithrombotic therapies), as well as in selecting the optimal candidates for clinical trials that aim to reduce this deleterious outcome. Emerging data suggest that brain and vascular imaging biomarkers may be particularly relevant since they provide insights into the ongoing acute stroke pathophysiology. In this review/perspective, we summarize the accumulating literature on the role of cerebrovascular imaging biomarkers in predicting post-EVT-associated intracerebral hemorrhage. We focus on imaging acquired before EVT, during the EVT procedure, and in the early post-EVT time frames when new therapeutic therapies could be tested. Accounting for the complex pathophysiology of post-EVT-associated intracerebral hemorrhage, this review may provide some guidance for future prospective observational or therapeutic studies.

Original languageEnglish (US)
Pages (from-to)2192-2203
Number of pages12
Issue number8
StatePublished - Aug 1 2023
Externally publishedYes


  • brain
  • brain ischemia
  • cerebral hemorrhage
  • magnetic resonance imaging
  • thrombectomy

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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