Role of B cells and antibodies in acquired immunity against Mycobacterium tuberculosis

Jacqueline M. Achkar, John Chan, Arturo Casadevall

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Accumulating evidence has documented a role for B cells and antibodies (Abs) in the immunity against Mycobacterium tuberculosis (Mtb). Passive transfer studies with monoclonal antibodies (mAbs) against mycobacterial antigens have shown protection against the tubercle bacillus. B cells and Abs are believed to contribute to an enhanced immune response against Mtb by modulating various immunological components in the infected host including the T-cell compartment. Nevertheless, the extent and contribution of B cells and Abs to protection against Mtb remains uncertain. In this article we summarize the most relevant findings supporting the role of B cells and Abs in the defense against Mtb and discuss the potential mechanisms of protection.

Original languageEnglish (US)
Article numbera018432
JournalCold Spring Harbor Perspectives in Medicine
Issue number3
StatePublished - 2015
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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