Role of acetylcholine in neurotransmission of the carotid body

Machiko Shirahata, Alexander Balbir, Toshiki Otsubo, Robert S. Fitzgerald

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Acetylcholine (ACh) has been considered an important excitatory neurotransmitter in the carotid body (CB). Its physiological and pharmacological effects, metabolism, release, and receptors have been well documented in several species. Various nicotinic and muscarinic ACh receptors are present in both afferent nerve endings and glomus cells. Therefore, ACh can depolarize or hyperpolarize the cell membrane depending on the available receptor type in the vicinity. Binding of ACh to its receptor can create a wide variety of cellular responses including opening cation channels (nicotinic ACh receptor activation), releasing Ca2+ from intracellular storage sites (via muscarinic ACh receptors), and modulating activities of K+ and Ca2+ channels. Interactions between ACh and other neurotransmitters (dopamine, adenosine, nitric oxide) have been known, and they may induce complicated responses. Cholinergic biology in the CB differs among species and even within the same species due to different genetic composition. Development and environment influence cholinergic biology. We discuss these issues in light of current knowledge of neuroscience.

Original languageEnglish (US)
Pages (from-to)93-105
Number of pages13
JournalRespiratory Physiology and Neurobiology
Issue number1
StatePublished - Jul 1 2007
Externally publishedYes


  • Channel
  • Muscarinic
  • Neurotransmitter
  • Nicotinic
  • Receptor

ASJC Scopus subject areas

  • General Neuroscience
  • Physiology
  • Pulmonary and Respiratory Medicine


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