@article{6e63d05c7d7d4ed8854d21d9c9809a09,
title = "Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage",
abstract = "Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic treatment for ICH and benefit poorly from this regimen. Inflammatory cytokines are important participants in secondary injury after ICH. Increases in proinflammatory cytokines may aggravate the tissue injury, whereas increases in anti-inflammatory cytokines might be protective in the ICH brain. Inflammatory cytokines have been studied as therapeutic targets in a variety of acute and chronic brain diseases; however, studies on ICH are limited. This review summarizes the roles and functions of various pro- and anti-inflammatory cytokines in secondary brain injury after ICH and discusses pathogenic mechanisms and emerging therapeutic strategies and directions for treatment of ICH.",
keywords = "Cytokines, ICH, Inflammatory reaction, Secondary injury",
author = "Huimin Zhu and Zhiqiang Wang and Jixu Yu and Xiuli Yang and Feng He and Zhenchuan Liu and Fengyuan Che and Xuemei Chen and Honglei Ren and Michael Hong and Jian Wang",
note = "Funding Information: FC is supported by the Key Research Project Program of Shandong Province of China (No. 2016GSF201056). JY is supported by the Shandong Provincial Natural Science Foundation of China (No. ZR2010HM041). JW is supported by National Institutes of Health grants (R01NS078026, R01AT007317, R01NS102583, and R01NS105894) and a Stimulating and Advancing ACCM Research (StAAR) award from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University. We thank Claire Levine, MS, ELS, Si Kun (Eddie) Wang, and Jiarui Wang for assistance with manuscript preparation and the Wang lab team members for insightful input. Funding Information: FC is supported by the Key Research Project Program of Shandong Province of China (No. 2016GSF201056 ). JY is supported by the Shandong Provincial Natural Science Foundation of China (No. ZR2010HM041 ). JW is supported by National Institutes of Health grants ( R01NS078026 , R01AT007317 , R01NS102583 , and R01NS105894 ) and a Stimulating and Advancing ACCM Research (StAAR) award from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University . We thank Claire Levine, MS, ELS, Si Kun (Eddie) Wang, and Jiarui Wang for assistance with manuscript preparation and the Wang lab team members for insightful input. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = jul,
doi = "10.1016/j.pneurobio.2019.03.003",
language = "English (US)",
volume = "178",
journal = "Progress in Neurobiology",
issn = "0301-0082",
publisher = "Elsevier Limited",
}