Rodent models of glaucoma

Thomas V. Johnson, Stanislav I. Tomarev

Research output: Contribution to journalReview articlepeer-review

110 Scopus citations


Glaucoma is a progressive, age-related optic neuropathy and a leading cause of irreversible blindness in the world. Animal models of glaucoma are essential to our continued efforts of elucidating the natural course of the disease and to developing therapeutic interventions to halt or reverse the progression of the condition. Over the past 10-15 years, rodents have become a popular model organism to study glaucoma, because of their high degree of availability, relatively low cost, short life-span, and amenability to experimental and genetic manipulation. In this review, we examine the numerous in vivo and in vitro rodent models of glaucoma, discuss the methods used to generate them, summarize some of the major findings obtained in these models, and identify individual strengths and weaknesses for the various systems.

Original languageEnglish (US)
Pages (from-to)349-358
Number of pages10
JournalBrain Research Bulletin
Issue number2-3
StatePublished - Feb 15 2010
Externally publishedYes


  • Animal models
  • Glaucoma
  • Intraocular pressure
  • Myocilin
  • Retina
  • Retinal ganglion cells
  • Rodent models

ASJC Scopus subject areas

  • Neuroscience(all)


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