TY - JOUR
T1 - Rodent models of glaucoma
AU - Johnson, Thomas V.
AU - Tomarev, Stanislav I.
N1 - Funding Information:
This research was supported by the Intramural Research Program of the National Eye Institute, National Institutes of Health; a National Institutes of Health Graduate Partnerships Program Fellowship (TVJ); and a Gates-Cambridge Scholarship (TVJ).
PY - 2010/2/15
Y1 - 2010/2/15
N2 - Glaucoma is a progressive, age-related optic neuropathy and a leading cause of irreversible blindness in the world. Animal models of glaucoma are essential to our continued efforts of elucidating the natural course of the disease and to developing therapeutic interventions to halt or reverse the progression of the condition. Over the past 10-15 years, rodents have become a popular model organism to study glaucoma, because of their high degree of availability, relatively low cost, short life-span, and amenability to experimental and genetic manipulation. In this review, we examine the numerous in vivo and in vitro rodent models of glaucoma, discuss the methods used to generate them, summarize some of the major findings obtained in these models, and identify individual strengths and weaknesses for the various systems.
AB - Glaucoma is a progressive, age-related optic neuropathy and a leading cause of irreversible blindness in the world. Animal models of glaucoma are essential to our continued efforts of elucidating the natural course of the disease and to developing therapeutic interventions to halt or reverse the progression of the condition. Over the past 10-15 years, rodents have become a popular model organism to study glaucoma, because of their high degree of availability, relatively low cost, short life-span, and amenability to experimental and genetic manipulation. In this review, we examine the numerous in vivo and in vitro rodent models of glaucoma, discuss the methods used to generate them, summarize some of the major findings obtained in these models, and identify individual strengths and weaknesses for the various systems.
KW - Animal models
KW - Glaucoma
KW - Intraocular pressure
KW - Myocilin
KW - Retina
KW - Retinal ganglion cells
KW - Rodent models
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U2 - 10.1016/j.brainresbull.2009.04.004
DO - 10.1016/j.brainresbull.2009.04.004
M3 - Review article
C2 - 19379796
AN - SCOPUS:73149117531
SN - 0361-9230
VL - 81
SP - 349
EP - 358
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 2-3
ER -