TY - JOUR
T1 - RNA in unexpected places
T2 - Long non-coding RNA functions in diverse cellular contexts
AU - Geisler, Sarah
AU - Coller, Jeff
N1 - Funding Information:
The authors are most grateful to T. Nilsen and K. Baker for insights and suggestions. The authors regret that not all contributions of their colleagues could be discussed due to space constraints. Work in the authors’ laboratory is funded by the National Institute of General Medical Sciences (NIGMS) (GM080465).
PY - 2013
Y1 - 2013
N2 - The increased application of transcriptome-wide profiling approaches has led to an explosion in the number of documented long non-coding RNAs (lncRNAs). While these new and enigmatic players in the complex transcriptional milieu are encoded by a significant proportion of the genome, their functions are mostly unknown. Early discoveries support a paradigm in which lncRNAs regulate transcription via chromatin modulation, but new functions are steadily emerging. Given the biochemical versatility of RNA, lncRNAs may be used for various tasks, including post-transcriptional regulation, organization of protein complexes, cell-cell signalling and allosteric regulation of proteins.
AB - The increased application of transcriptome-wide profiling approaches has led to an explosion in the number of documented long non-coding RNAs (lncRNAs). While these new and enigmatic players in the complex transcriptional milieu are encoded by a significant proportion of the genome, their functions are mostly unknown. Early discoveries support a paradigm in which lncRNAs regulate transcription via chromatin modulation, but new functions are steadily emerging. Given the biochemical versatility of RNA, lncRNAs may be used for various tasks, including post-transcriptional regulation, organization of protein complexes, cell-cell signalling and allosteric regulation of proteins.
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U2 - 10.1038/nrm3679
DO - 10.1038/nrm3679
M3 - Review article
C2 - 24105322
AN - SCOPUS:84886252113
SN - 1471-0072
VL - 14
SP - 699
EP - 712
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 11
ER -