Risk stratification after recurrence of human papillomavirus (HPV)-related and non-HPV-related oropharyngeal cancer: Secondary analysis of NRG Oncology RTOG 0129 and 0522

Elaine O. Bigelow; Jonathan Harris; Carole Fakhry; Maura L. Gillison; Phuc Felix Nguyen-Tân; David I. Rosenthal; Steven J. Frank; Suresh G. Nair; Houda Bahig; John A. Ridge; Jimmy Caudell; Craig Donaldson; Bradley T. Clifford; George Shenouda; Michael J. Birrer; Yuhchyau Chen; Quynh Thu Le

doi:10.1002/hed.26915

Risk stratification after recurrence of human papillomavirus (HPV)-related and non-HPV-related oropharyngeal cancer: Secondary analysis of NRG Oncology RTOG 0129 and 0522

Elaine O. Bigelow, Jonathan Harris, Carole Fakhry, Maura L. Gillison, Phuc Felix Nguyen-Tân, David I. Rosenthal, Steven J. Frank, Suresh G. Nair, Houda Bahig, John A. Ridge, Jimmy Caudell, Craig Donaldson, Bradley T. Clifford, George Shenouda, Michael J. Birrer, Yuhchyau Chen, Quynh Thu Le

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background: No risk-stratification strategies exist for patients with recurrent oropharyngeal cancer (OPC). Methods: Retrospective analysis using data from prospective NRG Oncology clinical trials RTOG 0129 and 0522. Eligibility criteria included known p16 status and smoking history, and locoregional/distant recurrence. Overall survival (OS) was measured from date of recurrence. Recursive partitioning analysis was performed to produce mutually exclusive risk groups. Results: Hundred and fifty-four patients were included with median follow-up after recurrence of 3.9 years (range 0.04–9.0). The most important factors influencing survival were p16 status and type of recurrence, followed by surgical salvage and smoking history (≤20 vs. >20 pack-years). Three significantly different risk groups were identified. Patients in the low-, intermediate-, and high-risk groups had 2-year OS after recurrence of 81.1% (95%CI 68.5–93.7), 50.2% (95%CI 36.0–64.5), and 20.8% (95%CI 10.5–31.1), respectively. Conclusion: Patient and tumor characteristics may be used to stratify patients into risk groups at the time of OPC recurrence.

Original language	English (US)
Pages (from-to)	158-167
Number of pages	10
Journal	Head and Neck
Volume	44
Issue number	1
DOIs	https://doi.org/10.1002/hed.26915
State	Published - Jan 2022

Keywords

Radiation Therapy Oncology Group
human papillomavirus
recurrent oropharyngeal cancer
recursive partitioning analysis
survival

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.26915

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Bigelow, E. O., Harris, J., Fakhry, C., Gillison, M. L., Nguyen-Tân, P. F., Rosenthal, D. I., Frank, S. J., Nair, S. G., Bahig, H., Ridge, J. A., Caudell, J., Donaldson, C., Clifford, B. T., Shenouda, G., Birrer, M. J., Chen, Y., & Le, Q. T. (2022). Risk stratification after recurrence of human papillomavirus (HPV)-related and non-HPV-related oropharyngeal cancer: Secondary analysis of NRG Oncology RTOG 0129 and 0522. Head and Neck, 44(1), 158-167. https://doi.org/10.1002/hed.26915

Bigelow, EO, Harris, J, Fakhry, C, Gillison, ML, Nguyen-Tân, PF, Rosenthal, DI, Frank, SJ, Nair, SG, Bahig, H, Ridge, JA, Caudell, J, Donaldson, C, Clifford, BT, Shenouda, G, Birrer, MJ, Chen, Y & Le, QT 2022, 'Risk stratification after recurrence of human papillomavirus (HPV)-related and non-HPV-related oropharyngeal cancer: Secondary analysis of NRG Oncology RTOG 0129 and 0522', Head and Neck, vol. 44, no. 1, pp. 158-167. https://doi.org/10.1002/hed.26915

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title = "Risk stratification after recurrence of human papillomavirus (HPV)-related and non-HPV-related oropharyngeal cancer: Secondary analysis of NRG Oncology RTOG 0129 and 0522",

abstract = "Background: No risk-stratification strategies exist for patients with recurrent oropharyngeal cancer (OPC). Methods: Retrospective analysis using data from prospective NRG Oncology clinical trials RTOG 0129 and 0522. Eligibility criteria included known p16 status and smoking history, and locoregional/distant recurrence. Overall survival (OS) was measured from date of recurrence. Recursive partitioning analysis was performed to produce mutually exclusive risk groups. Results: Hundred and fifty-four patients were included with median follow-up after recurrence of 3.9 years (range 0.04–9.0). The most important factors influencing survival were p16 status and type of recurrence, followed by surgical salvage and smoking history (≤20 vs. >20 pack-years). Three significantly different risk groups were identified. Patients in the low-, intermediate-, and high-risk groups had 2-year OS after recurrence of 81.1% (95%CI 68.5–93.7), 50.2% (95%CI 36.0–64.5), and 20.8% (95%CI 10.5–31.1), respectively. Conclusion: Patient and tumor characteristics may be used to stratify patients into risk groups at the time of OPC recurrence.",

keywords = "Radiation Therapy Oncology Group, human papillomavirus, recurrent oropharyngeal cancer, recursive partitioning analysis, survival",

author = "Bigelow, {Elaine O.} and Jonathan Harris and Carole Fakhry and Gillison, {Maura L.} and Nguyen-T{\^a}n, {Phuc Felix} and Rosenthal, {David I.} and Frank, {Steven J.} and Nair, {Suresh G.} and Houda Bahig and Ridge, {John A.} and Jimmy Caudell and Craig Donaldson and Clifford, {Bradley T.} and George Shenouda and Birrer, {Michael J.} and Yuhchyau Chen and Le, {Quynh Thu}",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC.",

year = "2022",

month = jan,

doi = "10.1002/hed.26915",

language = "English (US)",

volume = "44",

pages = "158--167",

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T1 - Risk stratification after recurrence of human papillomavirus (HPV)-related and non-HPV-related oropharyngeal cancer

T2 - Secondary analysis of NRG Oncology RTOG 0129 and 0522

AU - Bigelow, Elaine O.

AU - Harris, Jonathan

AU - Fakhry, Carole

AU - Gillison, Maura L.

AU - Nguyen-Tân, Phuc Felix

AU - Rosenthal, David I.

AU - Frank, Steven J.

AU - Nair, Suresh G.

AU - Bahig, Houda

AU - Ridge, John A.

AU - Caudell, Jimmy

AU - Donaldson, Craig

AU - Clifford, Bradley T.

AU - Shenouda, George

AU - Birrer, Michael J.

AU - Chen, Yuhchyau

AU - Le, Quynh Thu

PY - 2022/1

Y1 - 2022/1

N2 - Background: No risk-stratification strategies exist for patients with recurrent oropharyngeal cancer (OPC). Methods: Retrospective analysis using data from prospective NRG Oncology clinical trials RTOG 0129 and 0522. Eligibility criteria included known p16 status and smoking history, and locoregional/distant recurrence. Overall survival (OS) was measured from date of recurrence. Recursive partitioning analysis was performed to produce mutually exclusive risk groups. Results: Hundred and fifty-four patients were included with median follow-up after recurrence of 3.9 years (range 0.04–9.0). The most important factors influencing survival were p16 status and type of recurrence, followed by surgical salvage and smoking history (≤20 vs. >20 pack-years). Three significantly different risk groups were identified. Patients in the low-, intermediate-, and high-risk groups had 2-year OS after recurrence of 81.1% (95%CI 68.5–93.7), 50.2% (95%CI 36.0–64.5), and 20.8% (95%CI 10.5–31.1), respectively. Conclusion: Patient and tumor characteristics may be used to stratify patients into risk groups at the time of OPC recurrence.

AB - Background: No risk-stratification strategies exist for patients with recurrent oropharyngeal cancer (OPC). Methods: Retrospective analysis using data from prospective NRG Oncology clinical trials RTOG 0129 and 0522. Eligibility criteria included known p16 status and smoking history, and locoregional/distant recurrence. Overall survival (OS) was measured from date of recurrence. Recursive partitioning analysis was performed to produce mutually exclusive risk groups. Results: Hundred and fifty-four patients were included with median follow-up after recurrence of 3.9 years (range 0.04–9.0). The most important factors influencing survival were p16 status and type of recurrence, followed by surgical salvage and smoking history (≤20 vs. >20 pack-years). Three significantly different risk groups were identified. Patients in the low-, intermediate-, and high-risk groups had 2-year OS after recurrence of 81.1% (95%CI 68.5–93.7), 50.2% (95%CI 36.0–64.5), and 20.8% (95%CI 10.5–31.1), respectively. Conclusion: Patient and tumor characteristics may be used to stratify patients into risk groups at the time of OPC recurrence.

KW - Radiation Therapy Oncology Group

KW - human papillomavirus

KW - recurrent oropharyngeal cancer

KW - recursive partitioning analysis

KW - survival

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JO - Head and Neck

JF - Head and Neck

IS - 1

ER -

Risk stratification after recurrence of human papillomavirus (HPV)-related and non-HPV-related oropharyngeal cancer: Secondary analysis of NRG Oncology RTOG 0129 and 0522

Abstract

Keywords

ASJC Scopus subject areas

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