Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1

Pauline Mendola; Kirsten B. Moysich; Jo L. Freudenheim; Peter G. Shields; Enrique F. Schisterman; Saxon Graham; John E. Vena; James R. Marshall; Christine B. Ambrosone

doi:10.1097/00001648-199811000-00018

Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1

Pauline Mendola, Kirsten B. Moysich, Jo L. Freudenheim, Peter G. Shields, Enrique F. Schisterman, Saxon Graham, John E. Vena, James R. Marshall, Christine B. Ambrosone

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Maternal smoking increases the risk of spontaneous abortion. Polymorphic N-acetyltransferase (NAT2) and glutathione S-transferase (GSTM1) affect metabolism of some mutagens found in tobacco smoke. Genotypes and smoking were studied in women with at least two spontaneous abortions (N = 32) and those with at least two livebirths (N = 179). Smoking slightly increased risk (odds ratio = 1.3; 95% confidence interval = 0.6-2.9), but NAT2 and GSTM1 did not. NAT2 or GSTM1 polymorphisms did not appreciably modify smoking-related risk.

Original language	English (US)
Pages (from-to)	666-668
Number of pages	3
Journal	Epidemiology
Volume	9
Issue number	6
DOIs	https://doi.org/10.1097/00001648-199811000-00018
State	Published - Nov 1998
Externally published	Yes

Keywords

Gene-environment interaction
Genetic polymorphism
Glutathione S-transferase M1
Molecular epidemiology
N-acetyltransferase 2
Spontaneous abortion

ASJC Scopus subject areas

Epidemiology

Access to Document

10.1097/00001648-199811000-00018

Cite this

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title = "Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1",

abstract = "Maternal smoking increases the risk of spontaneous abortion. Polymorphic N-acetyltransferase (NAT2) and glutathione S-transferase (GSTM1) affect metabolism of some mutagens found in tobacco smoke. Genotypes and smoking were studied in women with at least two spontaneous abortions (N = 32) and those with at least two livebirths (N = 179). Smoking slightly increased risk (odds ratio = 1.3; 95% confidence interval = 0.6-2.9), but NAT2 and GSTM1 did not. NAT2 or GSTM1 polymorphisms did not appreciably modify smoking-related risk.",

keywords = "Gene-environment interaction, Genetic polymorphism, Glutathione S-transferase M1, Molecular epidemiology, N-acetyltransferase 2, Spontaneous abortion",

author = "Pauline Mendola and Moysich, {Kirsten B.} and Freudenheim, {Jo L.} and Shields, {Peter G.} and Schisterman, {Enrique F.} and Saxon Graham and Vena, {John E.} and Marshall, {James R.} and Ambrosone, {Christine B.}",

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AU - Mendola, Pauline

AU - Moysich, Kirsten B.

AU - Freudenheim, Jo L.

AU - Shields, Peter G.

AU - Schisterman, Enrique F.

AU - Graham, Saxon

AU - Vena, John E.

AU - Marshall, James R.

AU - Ambrosone, Christine B.

PY - 1998/11

Y1 - 1998/11

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AB - Maternal smoking increases the risk of spontaneous abortion. Polymorphic N-acetyltransferase (NAT2) and glutathione S-transferase (GSTM1) affect metabolism of some mutagens found in tobacco smoke. Genotypes and smoking were studied in women with at least two spontaneous abortions (N = 32) and those with at least two livebirths (N = 179). Smoking slightly increased risk (odds ratio = 1.3; 95% confidence interval = 0.6-2.9), but NAT2 and GSTM1 did not. NAT2 or GSTM1 polymorphisms did not appreciably modify smoking-related risk.

KW - Gene-environment interaction

KW - Genetic polymorphism

KW - Glutathione S-transferase M1

KW - Molecular epidemiology

KW - N-acetyltransferase 2

KW - Spontaneous abortion

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Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1

Abstract

Keywords

ASJC Scopus subject areas

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