TY - JOUR
T1 - Risk of physical injuries in children and teens with ophthalmic diagnoses in the OptumLabs Data Warehouse
AU - Pineles, Stacy L.
AU - Repka, Michael X.
AU - Yu, Fei
AU - Velez, Federico G.
AU - Doppee, Danielle
AU - Perez, Claudia
AU - Sim, Danielle
AU - Coleman, Anne L.
N1 - Funding Information:
Financial support: NIH/NEI 5R21EY029655-02 (SLP), unrestricted grant from Research to Prevent Blindness (SLP, ALC, FGV, MXR). The funding organizations had no role in the design or conduct of this research.
Funding Information:
Financial support: NIH / NEI 5R21EY029655-02 (SLP), unrestricted grant from Research to Prevent Blindness (SLP, ALC, FGV, MXR). The funding organizations had no role in the design or conduct of this research.
Publisher Copyright:
© 2021 American Association for Pediatric Ophthalmology and Strabismus
PY - 2021/12
Y1 - 2021/12
N2 - Background: To evaluate how eye diseases affect the risk of injuries (fractures, musculoskeletal, head and eye injuries) in children and teens. Methods: Claims from the OptumLabs Data Warehouse, a longitudinal deidentified commercial insurance claims database, were analyzed. Eligible subjects were aged <19 years at the time of their eye disease diagnosis, enrolled in the health plan between 2007 and 2018, and had >1 visit for >1 significant eye disease (strabismus, amblyopia, nystagmus, structural diseases), based on ICD9/10 codes. Controls were children in the same database who had no eye disease codes reported. Demographics and injury claims (fractures, musculoskeletal injuries, head injuries and eye injuries) were compared. Results: The overall incidence of any subsequent physical injury (even into adulthood) was 29% in eye disease patients and 23% in controls (P < 0.001). After accounting for covariates, the hazard ratio for injury with any type of eye disease was 1.14 (95% CI, 1.13-1.15), 1.17 (95% CI, 1.16-1.18), 0.97 (95% CI, 0.96-0.98), and 1.63 (95% CI, 1.60-1.66) for musculoskeletal injuries, fractures, head injuries, and eye injuries, respectively. The eye disease with the highest adjusted injury risk was nystagmus (HR = 1.26; 95% CI, 1.23-1.28), followed by optic neuritis and pseudotumor cerebri (HR = 1.25). The eye diseases with the lowest risk included amblyopia, esotropia, and glaucoma (HR ≤ 1.06). Conclusions: There was an increased long-term risk of physical injury among children and teens with eye disease. The clinical significance of these small differences is unclear.[Formula
AB - Background: To evaluate how eye diseases affect the risk of injuries (fractures, musculoskeletal, head and eye injuries) in children and teens. Methods: Claims from the OptumLabs Data Warehouse, a longitudinal deidentified commercial insurance claims database, were analyzed. Eligible subjects were aged <19 years at the time of their eye disease diagnosis, enrolled in the health plan between 2007 and 2018, and had >1 visit for >1 significant eye disease (strabismus, amblyopia, nystagmus, structural diseases), based on ICD9/10 codes. Controls were children in the same database who had no eye disease codes reported. Demographics and injury claims (fractures, musculoskeletal injuries, head injuries and eye injuries) were compared. Results: The overall incidence of any subsequent physical injury (even into adulthood) was 29% in eye disease patients and 23% in controls (P < 0.001). After accounting for covariates, the hazard ratio for injury with any type of eye disease was 1.14 (95% CI, 1.13-1.15), 1.17 (95% CI, 1.16-1.18), 0.97 (95% CI, 0.96-0.98), and 1.63 (95% CI, 1.60-1.66) for musculoskeletal injuries, fractures, head injuries, and eye injuries, respectively. The eye disease with the highest adjusted injury risk was nystagmus (HR = 1.26; 95% CI, 1.23-1.28), followed by optic neuritis and pseudotumor cerebri (HR = 1.25). The eye diseases with the lowest risk included amblyopia, esotropia, and glaucoma (HR ≤ 1.06). Conclusions: There was an increased long-term risk of physical injury among children and teens with eye disease. The clinical significance of these small differences is unclear.[Formula
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U2 - 10.1016/j.jaapos.2021.07.007
DO - 10.1016/j.jaapos.2021.07.007
M3 - Article
C2 - 34655769
AN - SCOPUS:85119193830
SN - 1091-8531
VL - 25
SP - 346.e1-346.e7
JO - Journal of AAPOS
JF - Journal of AAPOS
IS - 6
ER -