Risk factors of familial pancreatic cancer in Japan: Current smoking and recent onset of diabetes

Hiroyuki Matsubayashi, Atsuyuki Maeda, Hideyuki Kanemoto, Katsuhiko Uesaka, Kentaro Yamazaki, Shuichi Hironaka, Yuji Miyagi, Hisatomo Ikehara, Hiroyuki Ono, Alison Klein, Michael Goggins

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Objectives: In western countries, 7% to 10% of patients with pancreatic cancer (PC) have a familial predisposition to their disease. The aim of this study was to determine the familial susceptibility to PC in Japan. Methods: Five hundred seventy-seven patients with PC and 577 age- and gender-matched controls were analyzed for cancer history in their first-degree relative(s) (FDRs) and demographic factors. Results: The patients with PC were more likely to have an FDR with PC (6.9%) than the controls (2.9%; odds ratio [OR], 2.5; P = 0.02). Three patients (0.5%), but none of the controls, had a family history of PC in multiple FDRs. Smoking, especially current smoking (OR, 1.5; P = 0.005), and diabetes mellitus (OR: 1.7, P = 0.001) were also associated with PC. The odds increased up to 10-fold if the patients were positive for these 3 factors. The patients with familial PC were more likely to be current smokers (40%) and to have diabetes mellitus (32.5%) than the sporadic cases (30.1% and 20.1%; OR, 1.6 and 1.9). Conclusions: A family history of PC is a risk of PC in Japan (6.9%) as is a personal history of diabetes and smoking. It is prudent to inform the kindred of patients with familiar PC of the risk of smoking and to follow carefully if they develop diabetes.

Original languageEnglish (US)
Pages (from-to)974-978
Number of pages5
Issue number6
StatePublished - Aug 2011


  • Japan
  • early detection
  • familial pancreatic cancer
  • family history
  • pancreatic cancer
  • risk factor

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


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