Risk factors for the development of bronchiectasis in HIV-infected children

David M. Berman, Damaris Mafut, Boris Djokic, Gwendolyn Scott, Charles Mitchell

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Our objective was to describe the risk factors for the development of bronchiectasis in HIV-1 infected children. This study was a retrospective, case controlled study based upon medical record review of HIV-1 infected children receiving primary care at a single large, urban medical center in Miami, Florida. Cases (HIV-1 infected children who developed bronchiectasis while being cared for between January 1982 and September 2000) were matched 1:3 (birth ± 24 months) with controls (HIV-1 infected children without bronchiectasis). Variables analyzed including number of episodes of pneumonia (including Pneumocystis proved pneumonitis [PCP], lymphoid interstitial pneumonitis (LIP), and CDC category of immunosuppression) were noted in both cases and controls until the age at which the cases developed bronchiectasis. Of the 749 patients whose charts were reviewed, 43 met the case definition for bronchiectasis and 19 met the eligibility criteria for this study. Fifty-seven controls were randomly selected from the patients without bronchiectasis. Cases were more likely to have experienced recurrent pneumonia than the controls; 17 (89.5%) versus 5 children (8.8%) respectively (P-value ≤0.001) as well as a greater mean number of episodes of pneumonia 8.2 (range, 4-13) versus 1.45 (range, 0-9) respectively (CI = (5.58,7.82); P-value ≤0.001). Cases were more likely to have progressed to CDC immunological category 3 than the controls; 19(100%) versus 32 (56%) children respectively (P-value <0.001). LIP occurred more frequently in the cases than in the controls; 14/19 (73.6%) versus 19/57 (33.3%), respectively (P-value = 0.005). HIV-1 infected children with a history of recurrent pneumonia, profound immuno-suppression (CDC immunologic category 3), and LIP appear to have a higher risk of developing bronchiectasis.

Original languageEnglish (US)
Pages (from-to)871-875
Number of pages5
JournalPediatric pulmonology
Issue number10
StatePublished - Oct 2007


  • Bronchiectasis
  • Chronic lung disease
  • LIP
  • PCP
  • Recurrent pneumonia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Risk factors for the development of bronchiectasis in HIV-infected children'. Together they form a unique fingerprint.

Cite this