Risk factors for mortality in children with Candidemia

Theoklis E. Zaoutis; Susan E. Coffin; Jaclyn H. Chu; Kateri Heydon; Huaqing Zhao; H. Mollie Greves; Thomas J. Walsh

doi:10.1097/01.inf.0000172938.76561.8e

Risk factors for mortality in children with Candidemia

Theoklis E. Zaoutis, Susan E. Coffin, Jaclyn H. Chu, Kateri Heydon, Huaqing Zhao, H. Mollie Greves, Thomas J. Walsh

School of Medicine

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

We performed a retrospective cohort study of hospitalized children with positive blood cultures for Candida species. Independent risk factors for mortality by multivariable analysis were location in the pediatric intensive care unit at the time of infection (hazard ratio, 6.3; 95% confidence interval, 1.6-24.3) and the presence of an arterial catheter (hazard ratio, 2.4; 95% confidence interval, 1.1-5.8). Our findings help identify a group of pediatric patients that should be targeted for future interventions to prevent and treat candidemia.

Original language	English (US)
Pages (from-to)	736-739
Number of pages	4
Journal	Pediatric Infectious Disease Journal
Volume	24
Issue number	8
DOIs	https://doi.org/10.1097/01.inf.0000172938.76561.8e
State	Published - Aug 2005

Keywords

Candidemia
Fungal infections
Invasive candidiasis
Mortality
Pediatric

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

Access to Document

10.1097/01.inf.0000172938.76561.8e

Cite this

@article{abf6333cbecd40b18c60ab66ca2bf4b6,

title = "Risk factors for mortality in children with Candidemia",

abstract = "We performed a retrospective cohort study of hospitalized children with positive blood cultures for Candida species. Independent risk factors for mortality by multivariable analysis were location in the pediatric intensive care unit at the time of infection (hazard ratio, 6.3; 95% confidence interval, 1.6-24.3) and the presence of an arterial catheter (hazard ratio, 2.4; 95% confidence interval, 1.1-5.8). Our findings help identify a group of pediatric patients that should be targeted for future interventions to prevent and treat candidemia.",

keywords = "Candidemia, Fungal infections, Invasive candidiasis, Mortality, Pediatric",

author = "Zaoutis, {Theoklis E.} and Coffin, {Susan E.} and Chu, {Jaclyn H.} and Kateri Heydon and Huaqing Zhao and Greves, {H. Mollie} and Walsh, {Thomas J.}",

note = "Funding Information: Supported in part by Center for Education and Research on Therapeutics grant U-18-HS10399 from the Agency of Healthcare Research and Quality. ",

year = "2005",

month = aug,

doi = "10.1097/01.inf.0000172938.76561.8e",

language = "English (US)",

volume = "24",

pages = "736--739",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins",

number = "8",

}

TY - JOUR

T1 - Risk factors for mortality in children with Candidemia

AU - Zaoutis, Theoklis E.

AU - Coffin, Susan E.

AU - Chu, Jaclyn H.

AU - Heydon, Kateri

AU - Zhao, Huaqing

AU - Greves, H. Mollie

AU - Walsh, Thomas J.

N1 - Funding Information: Supported in part by Center for Education and Research on Therapeutics grant U-18-HS10399 from the Agency of Healthcare Research and Quality.

PY - 2005/8

Y1 - 2005/8

N2 - We performed a retrospective cohort study of hospitalized children with positive blood cultures for Candida species. Independent risk factors for mortality by multivariable analysis were location in the pediatric intensive care unit at the time of infection (hazard ratio, 6.3; 95% confidence interval, 1.6-24.3) and the presence of an arterial catheter (hazard ratio, 2.4; 95% confidence interval, 1.1-5.8). Our findings help identify a group of pediatric patients that should be targeted for future interventions to prevent and treat candidemia.

AB - We performed a retrospective cohort study of hospitalized children with positive blood cultures for Candida species. Independent risk factors for mortality by multivariable analysis were location in the pediatric intensive care unit at the time of infection (hazard ratio, 6.3; 95% confidence interval, 1.6-24.3) and the presence of an arterial catheter (hazard ratio, 2.4; 95% confidence interval, 1.1-5.8). Our findings help identify a group of pediatric patients that should be targeted for future interventions to prevent and treat candidemia.

KW - Candidemia

KW - Fungal infections

KW - Invasive candidiasis

KW - Mortality

KW - Pediatric

UR - http://www.scopus.com/inward/record.url?scp=23744504428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744504428&partnerID=8YFLogxK

U2 - 10.1097/01.inf.0000172938.76561.8e

DO - 10.1097/01.inf.0000172938.76561.8e

M3 - Article

C2 - 16094234

AN - SCOPUS:23744504428

SN - 0891-3668

VL - 24

SP - 736

EP - 739

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 8

ER -

Risk factors for mortality in children with Candidemia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this