Risk factors for emergence of resistance to broad-spectrum cephalosporins among Enterobacter spp.

K. S. Kaye; S. Cosgrove; A. Harris; G. M. Eliopoulos; Y. Carmeli

doi:10.1128/AAC.45.9.2628-2630.2001

Risk factors for emergence of resistance to broad-spectrum cephalosporins among Enterobacter spp.

K. S. Kaye, S. Cosgrove, A. Harris, G. M. Eliopoulos, Y. Carmeli

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

Among 477 patients with susceptible Enterobacter spp., 49 subsequently harbored third-generation cephalosporin-resistant Enterobacter spp. Broad-spectrum cephalosporins were independent risk factors for resistance (relative risk [OR] = 2.3, P = 0.01); quinolone therapy was protective (OR = 0.4, P = 0.03). There were trends toward decreased risk for resistance among patients receiving broad-spectrum cephalosporins and either aminoglycosides or imipenem. Of the patients receiving broad-spectrum cephalosporins, 19% developed resistance.

Original language	English (US)
Pages (from-to)	2628-2630
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	45
Issue number	9
DOIs	https://doi.org/10.1128/AAC.45.9.2628-2630.2001
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.45.9.2628-2630.2001

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abstract = "Among 477 patients with susceptible Enterobacter spp., 49 subsequently harbored third-generation cephalosporin-resistant Enterobacter spp. Broad-spectrum cephalosporins were independent risk factors for resistance (relative risk [OR] = 2.3, P = 0.01); quinolone therapy was protective (OR = 0.4, P = 0.03). There were trends toward decreased risk for resistance among patients receiving broad-spectrum cephalosporins and either aminoglycosides or imipenem. Of the patients receiving broad-spectrum cephalosporins, 19% developed resistance.",

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AU - Eliopoulos, G. M.

AU - Carmeli, Y.

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AB - Among 477 patients with susceptible Enterobacter spp., 49 subsequently harbored third-generation cephalosporin-resistant Enterobacter spp. Broad-spectrum cephalosporins were independent risk factors for resistance (relative risk [OR] = 2.3, P = 0.01); quinolone therapy was protective (OR = 0.4, P = 0.03). There were trends toward decreased risk for resistance among patients receiving broad-spectrum cephalosporins and either aminoglycosides or imipenem. Of the patients receiving broad-spectrum cephalosporins, 19% developed resistance.

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Risk factors for emergence of resistance to broad-spectrum cephalosporins among Enterobacter spp.

Abstract

ASJC Scopus subject areas

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