Risk factors for drug allergy

N. Franklin Adkinson

Research output: Contribution to journalArticlepeer-review

116 Scopus citations


Judging from available data on penicillin allergy there appear to be multiple definable risk factors for drug-induced immunopathology. The induction of a drug-specific immune response can be influenced by the age of the patient; underlying genetic or metabolic factors, which may restrict ability to initiate a drug-specific immune response; the chemical properties of the drug, largely its protein reactivity; and the dose and duration of treatment as well as the route of drug administration. The elicitation of drug-induced immunopathology is a function of the persistence of a drug-specific immune response; the frequency of drug treatment and its dose and duration; and probable constitutional factors that may determine in an important way the efficiency with which a drug-specific immune response can be translated into a systemic allergic reaction.

Original languageEnglish (US)
Pages (from-to)567-572
Number of pages6
JournalThe Journal of allergy and clinical immunology
Issue number4 PART 2
StatePublished - Oct 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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